Complementary DNA cloning of complement C8. beta. and its sequence homology to C9

Journal Article · Tue Jun 16 04:00:00 EDT 1987 · Biochemistry; (United States)

DOI:https://doi.org/10.1021/bi00386a045· OSTI ID:6375139

Haefliger, J A; Tschopp, J; Nardelli, D; Wahli, W; Kocher, H P; Tosi, M; Stanley, K K

The complete amino acid sequence of mature C8..beta.. has been derived from the DNA sequence of a cDNA clone identified by expression screening of a human liver cDNA library. Comparison with the amino acid sequence of C9 shows an overall homology with few deletions and insertions. In particular, the cysteine-rich domains and membrane-inserting regions of C9 are well conserved. These findings are discussed in relation to a possible mechanism of membrane attack complex formation.

• Research Organization: Universite de Lausanne, Epalinges, Switzerland
• OSTI ID: 6375139
• Journal Information: Biochemistry; (United States), Journal Name: Biochemistry; (United States) Vol. 26:12; ISSN BICHA
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACID SEQUENCE
ANIMALS
CARBOHYDRATES
CELL CONSTITUENTS
CELL MEMBRANES
CLONING
COMPLEMENT
DNA
DNA SEQUENCING
DNA-CLONING
GLUCOPROTEINS
MAMMALS
MAN
MEMBRANES
MOLECULAR STRUCTURE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
PRIMATES
PROTEINS
RECOMBINANT DNA
SACCHARIDES
STRUCTURAL CHEMICAL ANALYSIS
VERTEBRATES