Delisting toxicity evaluation of HTH and oxone(trade name) decontaminated VX. Final report, July 1989-March 1990
The acute percutaneous (bare skin) LD50 was determined for EA 2192 in the rabbit. Also established were the effective doses (ED50s) for the major toxic signs observed. Dermal, Department of Transportation (DOT), tests with rabbits indicated that VX/HTH decontaminated waste is a Class B poison after being aged only 24 hr following initiation of the decontamination procedure. The same reaction, when allowed to age through about 2 half-lives (28-30 days), was no longer a Class B poison and was nonhazardous by Code of Maryland Regulations (COMAR) toxicity criteria. The DOT tests with OXONE decontaminated/neutralized VX showed this solution to be less than a Class B poison by all three routes of administration (rat oral, rat inhalation, and rabbit dermal) after only 24-hr aging and a nonhazardous material by COMAR toxicity criteria.... vx, Rat, Half-life, ED50, EA 2192, Rabbit, COMAR, Decontaminated/Neutralized, HTH, OXONE, LD50.
- Research Organization:
- Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 6374175
- Report Number(s):
- AD-A-262999/6/XAB; CRDEC-TR-382
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CALCIUM COMPOUNDS
TOXICITY
ACID NEUTRALIZING CAPACITY
AGING
CALCIUM
CLASSIFICATION
DECONTAMINATION
DOSES
HALF-LIFE
HAZARDOUS MATERIALS
HAZARDS
INHALATION
MARYLAND
RABBITS
REGULATIONS
SAFETY STANDARDS
SKIN
TRADE
US DOT
WASTE DISPOSAL
WASTE MANAGEMENT
WASTES
ALKALINE EARTH METAL COMPOUNDS
ALKALINE EARTH METALS
ANIMALS
BODY
CHEMISTRY
CLEANING
DAYS LIVING RADIOISOTOPES
DEVELOPED COUNTRIES
ELEMENTS
INTAKE
ISOTOPES
MAMMALS
MANAGEMENT
MATERIALS
METALS
NATIONAL ORGANIZATIONS
NORTH AMERICA
ORGANS
RADIOISOTOPES
STANDARDS
US ORGANIZATIONS
USA
VERTEBRATES
WATER CHEMISTRY
YEARS LIVING RADIOISOTOPES
560300* - Chemicals Metabolism & Toxicology