Delisting toxicity evaluation of HTH and oxone(trade name) decontaminated VX. Final report, July 1989-March 1990
The acute percutaneous (bare skin) LD50 was determined for EA 2192 in the rabbit. Also established were the effective doses (ED50s) for the major toxic signs observed. Dermal, Department of Transportation (DOT), tests with rabbits indicated that VX/HTH decontaminated waste is a Class B poison after being aged only 24 hr following initiation of the decontamination procedure. The same reaction, when allowed to age through about 2 half-lives (28-30 days), was no longer a Class B poison and was nonhazardous by Code of Maryland Regulations (COMAR) toxicity criteria. The DOT tests with OXONE decontaminated/neutralized VX showed this solution to be less than a Class B poison by all three routes of administration (rat oral, rat inhalation, and rabbit dermal) after only 24-hr aging and a nonhazardous material by COMAR toxicity criteria.... vx, Rat, Half-life, ED50, EA 2192, Rabbit, COMAR, Decontaminated/Neutralized, HTH, OXONE, LD50.
- Research Organization:
- Chemical Research, Development and Engineering Center, Aberdeen Proving Ground, MD (United States)
- OSTI ID:
- 6374175
- Report Number(s):
- AD-A-262999/6/XAB; CRDEC-TR--382
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACID NEUTRALIZING CAPACITY
AGING
ALKALINE EARTH METAL COMPOUNDS
ALKALINE EARTH METALS
ANIMALS
BODY
CALCIUM
CALCIUM COMPOUNDS
CHEMISTRY
CLASSIFICATION
CLEANING
DAYS LIVING RADIOISOTOPES
DECONTAMINATION
DEVELOPED COUNTRIES
DOSES
ELEMENTS
HALF-LIFE
HAZARDOUS MATERIALS
HAZARDS
INHALATION
INTAKE
ISOTOPES
MAMMALS
MANAGEMENT
MARYLAND
MATERIALS
METALS
NATIONAL ORGANIZATIONS
NORTH AMERICA
ORGANS
RABBITS
RADIOISOTOPES
REGULATIONS
SAFETY STANDARDS
SKIN
STANDARDS
TOXICITY
TRADE
US DOT
US ORGANIZATIONS
USA
VERTEBRATES
WASTE DISPOSAL
WASTE MANAGEMENT
WASTES
WATER CHEMISTRY
YEARS LIVING RADIOISOTOPES