Distribution of angiotensin converting enzyme in sheep hypothalamus and medulla oblongata visualized by in vitro autoradiography

Journal Article · Thu Jan 01 04:00:00 EST 1987 · Clin. Exp. Hypertens., Part A; (United States)

DOI:https://doi.org/10.3109/10641968709164212· OSTI ID:6372558

Chai, S Y; McKinley, M J; Mendelsohn, F A

In vitro autoradiographic mapping of angiotensin converting enzyme (ACE) in sheep brain using the specific ACE inhibitor, /sup 125/I-351A, revealed very high densities of binding in large blood vessels and choroid plexus. In the a very high density of labelling occurred in the organum vasculosum of the lamina terminalis and median eminence and a high density in the subfornical organ and moderate density in supraoptic, suprachiasmatic, arcuate and paraventricular nuclei. All fiber tracts were unlabelled. In the medulla oblongata, a very high density of binding was detected in the area postrema and a high density in the nucleus of the solitary tract and dorsal motor nucleus of the vagus; a moderate density was found in the substantia gelatinosa of the spinal tract and the inferior olivary nucleus.

• Research Organization: Univ. of Melbourne, Victoria, Australia
• OSTI ID: 6372558
• Journal Information: Clin. Exp. Hypertens., Part A; (United States), Journal Name: Clin. Exp. Hypertens., Part A; (United States) Vol. 9:2-3; ISSN CEHAD
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ANGIOTENSIN
ANIMALS
AUTORADIOGRAPHY
BIOCHEMICAL REACTION KINETICS
BODY
BRAIN
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
DISTRIBUTION
DOMESTIC ANIMALS
DRUGS
ENZYME INHIBITORS
ENZYMES
GLOBULINS
HYDROLASES
HYPOTHALAMUS
IN VITRO
KINETICS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HYDROLASES
PROTEINS
REACTION KINETICS
RUMINANTS
SHEEP
TISSUE DISTRIBUTION
VASOCONSTRICTORS
VERTEBRATES