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Structure of methyl thienyl ketone oxime studied by the paramagnetic-additive method

Journal Article · · J. Struct. Chem. (Engl. Transl.); (United States)
DOI:https://doi.org/10.1007/BF00751744· OSTI ID:6369816

The authors examine the E-Z isomerism of methyl thienyl ketone oxime (I), the initial product in the synthesis of 2-(2-thienyl)pyrrole, where they used PMR spectra transformed by shifting reagents. Lanthanide shifting reagents LSR can be used to advantage in solving such problems. The PMR spectrum of oxime I has the protons in the CH3 group responsible for two signals (sigma = 2.33 and 2.28 ppm), integral intensity ratio 1:3. The protons in the heterocyclic part also give two signals each. The addition of Eu(fod)3 to a solution containing a mixture of the two isomers of oxime I shifts the signals only for one isomer (the less intense), so the second isomer is not coordinated with the LSR under these conditions. They therefore examined the spectra of two specimens, in one of which there was 100% of the isomer having the strong-field signal and the other 95% of the isomer giving the weak-field one. In the absence of the other isomer, the strong-field one also coordinates with the LSR, as is evident from the PMR spectra, which also shows the observed paramagnetic shifts delta in Hz. The values of delta were derived with the oxime in substantial excess relative to the LSR. The signals from protons H-3 and H-5 overlap in the PMR spectra of specimens without added Eu(fod)3, so the assignment in the spectra of specimens containing LSR is of major importance. These signals have been assigned with allowance for the spin-spin interaction constants J for the protons in thiophenes.

Research Organization:
Irkutsk Institute of Organic Chemistry, Siberia, USSR
OSTI ID:
6369816
Journal Information:
J. Struct. Chem. (Engl. Transl.); (United States), Journal Name: J. Struct. Chem. (Engl. Transl.); (United States) Vol. 27:2; ISSN JSTCA
Country of Publication:
United States
Language:
English