Radiation injury to the canine thymus lymphohematopoietic stem cells - correlation with functional deficits. Technical report, 22 February 1984-30 November 1985

Technical Report · Wed Jun 04 04:00:00 EDT 1986

OSTI ID:6367944

Nold, J B; Benjamin, S A; Miller, G K

Immunologic and hematopoietic responses were studied in dogs following prenatal or neonatal irradiation to evaluate the effects of ionizing radiation on the developing lymphohematopoietic system. Pregnant beagle dams received abdominal Co-60 gamma radiation exposures (200 R) or sham-irradiations at 35 days of gestation. Offspring from a second group of dams received 173 R whole-body gamma radiation or sham-irradiation at 10 days of age. The mean calculated dose to each fetus or neonate was 1.5 Gray. These data show that prenatally or neonatally-irradiated dogs have significant postnatal immunologic and hematopoietic defects. The observation of altered lymphocyte subpopulations suggests altered immunoregulation and raises some important questions relating to radiation-induced immunodeficiency and increased susceptibility to clinical disease, including neoplasia.

• Research Organization: Colorado State Univ., Fort Collins (USA)
• OSTI ID: 6367944
• Report Number(s): AD-A-182861/5/XAB
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
BONE MARROW
CONNECTIVE TISSUE CELLS
DISEASES
DOGS
HEMATOPOIETIC SYSTEM
IMMUNITY
IMMUNOLOGY
IMMUNOSUPPRESSION
INJURIES
LEUKOCYTES
LYMPHATIC SYSTEM
LYMPHOCYTES
MAMMALS
MATERIALS
ORGANS
PREGNANCY
RADIATION EFFECTS
RADIATION INJURIES
SOMATIC CELLS
THYMUS
TISSUES
VERTEBRATES