Effect of 2,3,4-trimethylpentane on the ultrastructure of kidneys from normal versus castrated male rats

Technical Report · Tue Dec 31 23:00:00 EST 1985

OSTI ID:6367177

Mattie, D; Chase, M; Hobson, D

Studies in this laboratory have shown that exposure to vapors of hydrocarbon fuels such as JP-5, JP-4 and diesel fuel-marine produce kidney lesions, including protein deposition, proximal tubular cell degeneration and intratubular casts in male rats, but not in female rats. 2,2,4 trimethylpentane (TMP) is a principal component of gasoline. Both 2,2,4 TMP and its more potent isomer, 2,3,4 TMP, in gavage studies produced kidney lesions identical to those seen in acute fuel-inhalation exposures. Only male rats produce a testosterone dependent alpha 2u globulin, a low-molecular-weight plasma protein. Since this protein appears to be involved in the pathogenesis of the kidney lesion, castrated rats were also exposed to 2,3,4 TMP and examined by transmission electron microscopy. The purpose of this study was to examine the early pathogenesis of the kidney lesion in both normal and castrated rats following exposure to 2,3,4 TMP.

• Research Organization: Air Force Aerospace Medical Research Lab., Wright-Patterson AFB, OH (USA)
• OSTI ID: 6367177
• Report Number(s): AD-A-182179/2/XAB; AAMRL-TR-87-017
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKYL RADICALS
ANIMALS
BODY
DEPOSITION
DIESEL FUELS
ELECTRON MICROSCOPY
FEMALES
FUELS
GASOLINE
GLOBULINS
GONADS
HYDROCARBONS
JET ENGINE FUELS
KIDNEYS
LIQUID FUELS
MALE GENITALS
MALES
MAMMALS
METHYL RADICALS
MICROSCOPY
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PETROLEUM PRODUCTS
PROTEINS
RADICALS
RATS
RODENTS
TESTES
TOXICITY
VERTEBRATES