Disposition and elimination of two sequential doses of 2,4,5,2',4',5'-hexachlorobiphenyl
It has been suggested based on fecal elimination data that a second dose of 2,4,5,2',4',5'-hexachlorobiphenyl (6-CB) is eliminated more rapidly from male rats than a first dose of 6-CB due to a differential accumulation of the two 6-CB doses within individual adipocytes. This phenomenon was further examined and extended to assess tissue levels of the compound in male rats which received either 0.6 mg/kg unlabeled or /sup 14/C-6-CB iv (dose 1). Fourteen days later, those animals which had received unlabeled 6-CB were administered 0.6 mg/kg /sup 14/C-6-CB. One-half of those rats which had received /sup 14/C-6-CB as dose 1 were administered unlabeled 6-CB after 14 days, and the remainder did not receive a second dose. The fecal excretion of radiolabeled 6-CB from rats treated only with /sup 14/C-6-CB was 5.3% of the total dose from days 14 through 28 post-treatment. Those rats receiving /sup 14/C-6-CB followed by unlabeled 6-CB excreted 4.4% of the total radiolabeled dose. Animals treated with /sup 14/C-6-CB as the second dose excreted 9% of their total radiolabeled dose within 14 days of treatment and those receiving only /sup 14/C-6-CB excreted 11% over the same time interval. Urinary elimination of radioactivity was negligible in all treatment groups. The pattern of distribution of /sup 14/C-6-CB in tissues was similar among all treatment groups. These data suggest that a second dose of 6-CB is not distributed differently from the first in growing male rats.
- Research Organization:
- Medical College of Wisconsin, Milwaukee
- OSTI ID:
- 6365779
- Journal Information:
- Drug Metab. Dispos.; (United States), Journal Name: Drug Metab. Dispos.; (United States) Vol. 15:3; ISSN DMDSA
- Country of Publication:
- United States
- Language:
- English
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560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
AROMATICS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBON 14 COMPOUNDS
CHLORINATED AROMATIC HYDROCARBONS
CLEARANCE
CONNECTIVE TISSUE CELLS
DISTRIBUTION
EXCRETION
FAT CELLS
FECES
HALOGENATED AROMATIC HYDROCARBONS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
METABOLISM
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
RATS
RODENTS
SOMATIC CELLS
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
WASTES