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Title: Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells

Abstract

A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. He remained in complete remission for 18 mo, when he developed a chloroma in the perineum. The chloroma was treated with local radiotherapy. The chloroma recurred 8 mo later and was treated with radiotherapy followed by combination chemotherapy. At 34 mo after transplant, marrow relapse and chloroma were documented. The first chloroma contained host cells by fluorescent Y-chromatin body analyses of interphase nuclei. All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. A new consistent chromosome abnormality (45, X, -X, t(8;21) (q22; q22)) was observed in a majority of donor cells. The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment.

Authors:
; ;
Publication Date:
OSTI Identifier:
6364270
DOE Contract Number:  
EY-76-C-02-0069
Resource Type:
Journal Article
Journal Name:
Blood; (United States)
Additional Journal Information:
Journal Volume: 52:3
Country of Publication:
United States
Language:
English
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BONE MARROW; TRANSPLANTS; MYELOID LEUKEMIA; RADIOTHERAPY; TUMOR CELLS; CHROMOSOMAL ABERRATIONS; BIOCHEMISTRY; CHEMOTHERAPY; GENETICS; GRAFT-HOST REACTION; HEMATOPOIETIC SYSTEM; PATIENTS; ANIMAL CELLS; ANIMAL TISSUES; BIOLOGY; BODY; CHEMISTRY; DISEASES; HEMIC DISEASES; LEUKEMIA; MEDICINE; MUTATIONS; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIOLOGY; THERAPY; TISSUES; 550603* - Medicine- External Radiation in Therapy- (1980-); 550200 - Biochemistry; 550300 - Cytology; 550400 - Genetics

Citation Formats

Elfenbein, G.J., Brogaonkar, D.S., and Bias, W.B. Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells. United States: N. p., 1978. Web.
Elfenbein, G.J., Brogaonkar, D.S., & Bias, W.B. Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells. United States.
Elfenbein, G.J., Brogaonkar, D.S., and Bias, W.B. Fri . "Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells". United States.
@article{osti_6364270,
title = {Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells},
author = {Elfenbein, G.J. and Brogaonkar, D.S. and Bias, W.B.},
abstractNote = {A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. He remained in complete remission for 18 mo, when he developed a chloroma in the perineum. The chloroma was treated with local radiotherapy. The chloroma recurred 8 mo later and was treated with radiotherapy followed by combination chemotherapy. At 34 mo after transplant, marrow relapse and chloroma were documented. The first chloroma contained host cells by fluorescent Y-chromatin body analyses of interphase nuclei. All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. A new consistent chromosome abnormality (45, X, -X, t(8;21) (q22; q22)) was observed in a majority of donor cells. The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment.},
doi = {},
journal = {Blood; (United States)},
number = ,
volume = 52:3,
place = {United States},
year = {1978},
month = {9}
}