Cytogenetic evidence for recurrence of acute myelogenous leukemia after allogeneic bone marrow transplantation in donor hematopoietic cells
A 22-yr-old man with acute myelocytic leukemia received a bone marrow transplant from a genotypically HLA-identical female sibling after cyclophosphamide preparation. He remained in complete remission for 18 mo, when he developed a chloroma in the perineum. The chloroma was treated with local radiotherapy. The chloroma recurred 8 mo later and was treated with radiotherapy followed by combination chemotherapy. At 34 mo after transplant, marrow relapse and chloroma were documented. The first chloroma contained host cells by fluorescent Y-chromatin body analyses of interphase nuclei. All metaphase cells and karyotypes from peripheral blood and marrow samples showed no evidence of host cells from 3 wk after transplant through the time of marrow relapse. Data from autosomal and sex chromosome studies indicate that the marrow relapse occurred in cells of donor origin. A new consistent chromosome abnormality (45, X, -X, t(8;21) (q22; q22)) was observed in a majority of donor cells. The patient received a second bone marrow transplant from the same donor after preparation with busulfan and cyclophosphamide and attained a complete remission with full hematologic engraftment.
- DOE Contract Number:
- EY-76-C-02-0069
- OSTI ID:
- 6364270
- Journal Information:
- Blood; (United States), Vol. 52:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
BONE MARROW
TRANSPLANTS
MYELOID LEUKEMIA
RADIOTHERAPY
TUMOR CELLS
CHROMOSOMAL ABERRATIONS
BIOCHEMISTRY
CHEMOTHERAPY
GENETICS
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
PATIENTS
ANIMAL CELLS
ANIMAL TISSUES
BIOLOGY
BODY
CHEMISTRY
DISEASES
HEMIC DISEASES
LEUKEMIA
MEDICINE
MUTATIONS
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)
550200 - Biochemistry
550300 - Cytology
550400 - Genetics