Rapid determination of drugs and semivolatile organics by direct thermal desorption ion trap mass spectrometry
Direct thermal desorption of analytes into an ion trap mass spectrometer (ITMS) is being investigated as a technique for the rapid screening of a wide variety of samples for target semivolatile organic compounds. This includes the direct detection of drugs in physiological fluids, semivolatile organic pollutants in water and waste samples, and air pollutants collected on sorbent cartridges. In order to minimize the analysis time, chromatographic separation is not performed on the sample prior to introduction into the ITMS. Instead, selective chemical ionization and tandem mass spectrometry (MS/MS) are used achieve the specificity required for the target analytes. Detection limits are typically 10--50 ppb using a 1 uL aliquot of a liquid sample without preconcentration. Sample turn-around time is 2 to 5 minutes and 3 to 5 target analytes can be quantitatively determined simultaneously. 6 figs.
- Research Organization:
- Oak Ridge National Lab., TN (USA)
- Sponsoring Organization:
- USDOD; USDOE; NCI; Department of Defense, Washington, DC (USA); USDOE, Washington, DC (USA); National Cancer Inst., Bethesda, MD (USA)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 6358880
- Report Number(s):
- CONF-910278-3; ON: DE91008885
- Resource Relation:
- Conference: 2. international symposium on field screening methods for hazardous wastes and toxic chemicals, Las Vegas, NV (USA), 12-14 Feb 1991
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ORGANIC
PHYSICAL AND ANALYTICAL CHEMISTRY
DRUGS
MASS SPECTROSCOPY
ORGANIC COMPOUNDS
AIR POLLUTION
CHEMICAL ANALYSIS
COCAINE
SALIVA
URINE
ALKALOIDS
ANESTHETICS
ANTIDEPRESSANTS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY FLUIDS
CENTRAL NERVOUS SYSTEM AGENTS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
MATERIALS
POLLUTION
PSYCHOTROPIC DRUGS
SPECTROSCOPY
WASTES
400102* - Chemical & Spectral Procedures