Exposure to low levels of hydrogen sulfide elevates circulating glucose in maternal rats
- Univ. of Calgary, Alberta (Canada)
Although the lethal effect of hydrogen sulfide (H{sub 2}S) has long been known, the results of exposure to low levels of H{sub 2}S have not been well documented. Rat dams and pups were exposed to low levels of H{sub 2}S (less than or equal to 75 ppm) from d 1 of gestation until d 21 postpartum and analyzed for changes in circulating enzymatic activity and metabolites. Blood glucose was significantly elevated in maternal blood on d 21 postpartum at all exposure levels. This increase in glucose was accompanied by a possible decrease in serum triglyceride in the pups and in the dams on d 21 postpartum. There was no evidence of alterations in serum alkaline phosphatase, lactate dehydrogenase, or serum glutamate oxaloacetate transaminase.
- OSTI ID:
- 6358091
- Journal Information:
- Journal of Toxicology and Environmental Health; (USA), Journal Name: Journal of Toxicology and Environmental Health; (USA) Vol. 31:1; ISSN JTEHD; ISSN 0098-4108
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALDEHYDES
ANIMALS
BIOLOGICAL EFFECTS
BIOSYNTHESIS
CARBOHYDRATES
CHALCOGENIDES
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
ESTERS
GLUCOSE
HEXOSES
HYDROGEN COMPOUNDS
HYDROGEN SULFIDES
LIPIDS
MAMMALS
METABOLISM
METABOLITES
MONOSACCHARIDES
ORGANIC COMPOUNDS
RATS
RODENTS
SACCHARIDES
SULFIDES
SULFUR COMPOUNDS
SYNTHESIS
TRIGLYCERIDES
VERTEBRATES