Lung injury caused by ambient levels of ozone

Technical Report · Fri Jan 01 04:00:00 EST 1988

OSTI ID:6358003

Huang, Y; Chang, L Y; Miller, F J; Crapo, J D

Exposures to low levels of O{sub 3} cause epithelial and interstitial injury in the proximal alveolar region. The sequential development of this lesion caused by a simulated ambient pattern of O{sub 3} was studied by exposing Fisher 344 rats to 0.06ppm O{sub 3} overnight with an 8 hr daytime exposure having a slow increase to a peak of 0.25 ppm and then gradually decreasing back to 0.06 ppm. Animals were studied using EM morphometric techniques after 7, 21 and 90 days exposure as well as post 90 days exposures. The early changes in O{sub 3} exposed animals included increases of volumes in type II epithelium (60%), type I epithelium (16%), cellular interstitium (52%), non-cell interstitium (33%), and in alveolar macrophages (180%). The response showed a biphasic reaction with the early injury subsiding after 21 days of O{sub 3} exposure. The animals exposed for 90 days showed a 28% increase in relative volume of type I and a 42% increase in type II epithelia.

• Research Organization: Duke Univ., Durham, NC (USA). Medical Center
• OSTI ID: 6358003
• Report Number(s): PB-91-117606/XAB; CNN: EPA-R-813113
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ANIMAL CELLS
ANIMAL TISSUES
ANIMALS
BODY
CONNECTIVE TISSUE CELLS
EPITHELIUM
LUNGS
MACROPHAGES
MAMMALS
ORGANS
OZONE
PATHOLOGICAL CHANGES
PHAGOCYTES
POLLUTION
RATS
RESPIRATORY SYSTEM
RODENTS
SIMULATION
SOMATIC CELLS
TISSUES
TOXICITY
VERTEBRATES