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Studies with 17. beta. (16. cap alpha. -(/sup 125/I)iodo)-estradiol, an estrogen receptor-binding radiopharmaceutical, in rats bearing mammary tumors

Journal Article · · J. Nucl. Med.; (United States)
OSTI ID:6354921
; ; ;
We have studied the distribution of 17..beta..(16..cap alpha..-(/sup 125/I)iodo)-estradiol (I-E/sub 2/) in tumor-bearing and normal rats. High early adrenal-to-blood ratios (up to 22 at 5 min) were seen in all groups, but this fell to six at 1 h. Uterus-to-blood ratios of 15 were found, and these were fairly constant up to 2 h after administration. Uptake of label in the uterus, but not in the adrenals, was sensitive to excess diethylstilbestrol, which competes with I-E/sub 2/ for estrogen receptors. Mean tumor-to-blood ratios of 1.4, 5.5, 8.7 were seen at 1 h in rats with transplanted, spontaneous, and N-nitrosomethylurea-induced tumors, respectively. Better estrongen-receptor-binding radiopharmaceuticals can probably be designed.
Research Organization:
Univ. of Wisconsin Hospital, Madison
OSTI ID:
6354921
Journal Information:
J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 22:5; ISSN JNMEA
Country of Publication:
United States
Language:
English

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Related Subjects

550601 -- Medicine-- Unsealed Radionuclides in Diagnostics
560172* -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL GLANDS
ANIMALS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
ESTRADIOL
ESTRANES
ESTROGENS
FEMALE GENITALS
GLANDS
HORMONES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIVER
LUNGS
MAMMALS
MAMMARY GLANDS
MATERIALS
NEOPLASMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RATS
RECEPTORS
RESPIRATORY SYSTEM
RODENTS
STEROID HORMONES
STEROIDS
TISSUE DISTRIBUTION
UTERUS
VERTEBRATES