Microbial mutagenicity of isomeric two-, three-, and four-ring amino polycyclic aromatic hydrocarbons

Journal Article · Sun Jan 01 04:00:00 EST 1984 · Environ. Mutagen.; (United States)

DOI:https://doi.org/10.1002/em.2860060404· OSTI ID:6352912

Later, D W; Pelroy, R A; Stewart, D L; McFall, T; Booth, G M; Lee, M L; Tedjamulia, M; Castle, R N

The isomers of various two-, three-, and four-ring amino polycyclic aromatic hydrocarbons were tested for mutagenic activity using a microbial plate incorporation test with four Salmonella typhimurium strains (TA98, TA100, TA1535, and TA1537). All compounds were assayed with an S9 metabolic activating enzyme system. The two-ring compounds were tested only with TA98. All were weakly mutagenic except 2-aminobiphenyl, which was not mutagenic under these test conditions. All except two of the 13 fused three-ring compounds were active frame shift mutagens; only the aminophenanthrenes were active base-pair mutagens. As a group, the pericondensed four-ring amino compounds were the most mutagenic of the three groups tested. In general, the mutagenic potency of the amino polycyclic aromatic compounds tested was highly dependent on the structural position of the amino group.

• Research Organization: Pacific Northwest Laboratories, Richland, WA
• DOE Contract Number: AC06-76RL01830; AC02-79EV10237
• OSTI ID: 6352912
• Journal Information: Environ. Mutagen.; (United States), Journal Name: Environ. Mutagen.; (United States) Vol. 6:4; ISSN ENMUD
• Country of Publication: United States
• Language: English

Related Subjects

560302* -- Chemicals Metabolism & Toxicology-- Microorganisms-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AROMATICS
BACTERIA
DATA
EXPERIMENTAL DATA
HYDROCARBONS
INFORMATION
ISOMERS
METABOLIC ACTIVATION
MICROORGANISMS
MUTAGEN SCREENING
MUTAGENESIS
MUTANTS
NUMERICAL DATA
ORGANIC COMPOUNDS
POLYCYCLIC AROMATIC HYDROCARBONS
REVERTANTS
SALMONELLA
SALMONELLA TYPHIMURIUM
SCREENING