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Na/sup +/-H/sup +/ exchange and Na/sup +/-dependent transport systems in streptozotocin diabetic rat kidneys

Journal Article · · Am. J. Physiol.; (United States)
OSTI ID:6351852
; ; ; ;
The streptozotocin-induced diabetic rat was used to test the hypothesis that Na/sup +/-H/sup +/ exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of /sup 22/Na/sup +/, and stimulated /sup 22/Na= pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H/sup +/ gradient-dependent Na/sup +/ uptake and Na/sup +/ gradient-dependent H/sup +/ flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals. Na/sup +/ gradient-dependent uptakes of phosphate, D-glucose, L-proline, and myoinositol were decreased in the drug-induced diabetic animals. These membrane transport alterations were not found when the streptozotocin-diabetic animals were treated with insulin.
Research Organization:
National Institutes of Health, Baltimore, MD
OSTI ID:
6351852
Journal Information:
Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 252:1; ISSN AJPHA
Country of Publication:
United States
Language:
English

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Related Subjects

551001* -- Physiological Systems-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
AMINES
AMINO ACIDS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DIABETES MELLITUS
DISEASES
DRUGS
ENDOCRINE DISEASES
GLUCOSE
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HEXOSES
HYPERTROPHY
INOSITOLS
ISOTOPES
KIDNEYS
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MEMBRANE TRANSPORT
METABOLIC DISEASES
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORUS 32
PHOSPHORUS ISOTOPES
PHYSIOLOGY
PROLINE
PYRROLES
PYRROLIDINES
RADIOISOTOPES
RATS
RODENTS
SACCHARIDES
SODIUM 22
SODIUM CHLORIDES
SODIUM COMPOUNDS
SODIUM ISOTOPES
STREPTOZOCIN
TRITIUM COMPOUNDS
VERTEBRATES
YEARS LIVING RADIOISOTOPES