Na/sup +/-H/sup +/ exchange and Na/sup +/-dependent transport systems in streptozotocin diabetic rat kidneys
The streptozotocin-induced diabetic rat was used to test the hypothesis that Na/sup +/-H/sup +/ exchange activity in the proximal tubule luminal membrane would be increased in association with renal hypertrophy, altered glomerular hemodynamics, enhanced filtered load and tubular reabsorption of /sup 22/Na/sup +/, and stimulated /sup 22/Na= pump activity in the basolateral membrane, previously reported characteristics of this experimental animal model. Amiloride-sensitive H/sup +/ gradient-dependent Na/sup +/ uptake and Na/sup +/ gradient-dependent H/sup +/ flux were increased in brush-border membrane vesicles from the streptozotocin-treated animals. Na/sup +/ gradient-dependent uptakes of phosphate, D-glucose, L-proline, and myoinositol were decreased in the drug-induced diabetic animals. These membrane transport alterations were not found when the streptozotocin-diabetic animals were treated with insulin.
- Research Organization:
- National Institutes of Health, Baltimore, MD
- OSTI ID:
- 6351852
- Journal Information:
- Am. J. Physiol.; (United States), Vol. 252:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
KIDNEYS
PHYSIOLOGY
PHOSPHORUS 32
MEMBRANE TRANSPORT
SODIUM 22
DIABETES MELLITUS
GLUCOSE
HYPERTROPHY
INOSITOLS
PROLINE
RATS
SODIUM CHLORIDES
STREPTOZOCIN
TRITIUM COMPOUNDS
ALDEHYDES
ALKALI METAL COMPOUNDS
ALKALI METAL ISOTOPES
AMINES
AMINO ACIDS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBOXYLIC ACIDS
CHLORIDES
CHLORINE COMPOUNDS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ENDOCRINE DISEASES
HALIDES
HALOGEN COMPOUNDS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HEXOSES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
METABOLIC DISEASES
MONOSACCHARIDES
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
PHOSPHORUS ISOTOPES
PYRROLES
PYRROLIDINES
RADIOISOTOPES
RODENTS
SACCHARIDES
SODIUM COMPOUNDS
SODIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
551001* - Physiological Systems- Tracer Techniques