Myocardial uptake of thallium and rubidium during alterations in perfusion and oxygenation in isolated rabbit hearts

Journal Article · Fri May 01 04:00:00 EDT 1987 · J. Nucl. Med.; (United States)

OSTI ID:6351606

Leppo, J A

The comparative effects of altered cellular function and coronary perfusion on myocardial /sup 201/Tl and /sup 83/Rb uptake were evaluated in three groups of isolated rabbit hearts having isovolumic contractions. Paired-indication dilution experiments were performed with /sup 201/Tl, /sup 83/Rb, and /sup 111/In-labeled albumin as an intravascular reference marker. In Group A hearts (n = 12), isotope transport was determined during control, hypoxia, and ischemia. In Group B hearts (n = 8), isotope transport was measured at control flow and again at a 50% and 80% reduction. In Group C hearts (n = 8) only /sup 201/Tl uptake was determined at control and following coronary reperfusion. Myocardial /sup 201/Tl and /sup 83/Rb transport were not significantly different and were proportional to flow. Although all interventions caused significant hemodynamic alterations, neither tracer was affected by hypoxia at constant flow. Thallium-201 permeation, however, was transiently decreased immediately after coronary reperfusion. We conclude that myocardial uptake of /sup 201/Tl and /sup 83/Rb are similar and directly related to flow, but do not reflect hypoxia induced cellular dysfunction.

• Research Organization: Univ. of Massachusetts Medical Center, Worcester
• OSTI ID: 6351606
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

560162* -- Radionuclide Effects
Kinetics
& Toxicology-- Animals
Plants
Microorganisms
& Cells
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMALS
ANOXIA
BETA DECAY RADIOISOTOPES
BLOOD CIRCULATION
BODY
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
HEART
HEAVY NUCLEI
IN VITRO
INDIUM 111
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISCHEMIA
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
MUSCLES
MYOCARDIUM
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
OXYGEN
PERFUSED ORGANS
RABBITS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RUBIDIUM 83
RUBIDIUM ISOTOPES
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VASCULAR DISEASES
VERTEBRATES