Further evidence supporting the concurrent influence of aflatoxin and manganese

Journal Article · Wed Apr 01 00:00:00 EST 1987 · Vet. Hum. Toxicol.; (United States)

OSTI ID:6351101

Katzen, J S; Llewellyn, G C

Trace elements, including manganese may afford protection from deleterious effects of aflatoxin. Young male Fischer rats received ip injections of aflatoxin B1 (AFB1) in dimethyl sulfoxide (DMSO), 1 mg/kg, 2 mg/kg or 4 mg/kg. Control groups received DMSO ip or no injection. All animals were intubated with 3 microCi of (/sup 54/Mn)-MnCl/sub 2/ 12 hr post-injection. Sacrifice occurred 72 hr after gavage of the radiolabel. All tested levels of AFB1 affected the loss of total body radioactivity. This response was observed within 12 hr when toxin-treated groups excreted almost 4 times more counts than controls. From 12-36 hr following radiolabel administration, AFB1 appeared to enhance excretion; by 72 hr, toxin-treated animals (especially those receiving higher doses) appeared to conserve the metal. Aflatoxicosis manifested itself through reduced body weight gain. The data provide support evidence that Mn and AFB1 biointeract.

• Research Organization: Virginia Commonwealth Univ., Richmond
• OSTI ID: 6351101
• Journal Information: Vet. Hum. Toxicol.; (United States), Vol. 2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFLATOXIN
TOXICITY
MANGANESE
BIOLOGICAL EFFECTS
BIOCHEMICAL REACTION KINETICS
BODY BURDEN
CARCINOGENS
DMSO
FECES
MANGANESE 54
RATS
TRACER TECHNIQUES
ANIMALS
ANTIGENS
BETA DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
ELEMENTS
INTERMEDIATE MASS NUCLEI
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
MAMMALS
MANGANESE ISOTOPES
MATERIALS
METALS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
RODENTS
SULFOXIDES
TOXIC MATERIALS
TOXINS
TRANSITION ELEMENTS
VERTEBRATES
WASTES
560300* - Chemicals Metabolism & Toxicology