Diagnostic implications of Ga-67 chest-scan patterns in human immunodeficiency virus-seropositive patients

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.170.3.2536945· OSTI ID:6350920

Kramer, E L; Sanger, J H; Garay, S M; Grossman, R J; Tiu, S; Banner, H

Consecutive gallium-67 scans (n = 237) of 180 human immunodeficiency virus-seropositive patients with suspected pulmonary infections were evaluated for intensity and pattern of gallium distribution. Scan findings were correlated with the history, chest radiographic findings, and clinicopathologic diagnoses. Pneumocystis carinii pneumonia (PCP) occurred significantly more often with heterogeneous diffuse uptake than with homogeneous diffuse uptake. Heterogeneous diffuse uptake had an 87% positive predictive value for PCP, which was higher than that of other patterns. Localized pulmonary uptake was most commonly due to bacterial pneumonia or PCP; ill-defined, perihilar uptake, to cytomegalovirus or PCP; and focal (lymph node) uptake, to tuberculosis or lymphoma. The positive predictive value of any pulmonary uptake for lung pathology was 93%, and the negative predictive value of a negative scan was 96%. These findings confirm the utility of gallium scanning in the detection of lung pathology related to acquired immunodeficiency syndrome, particularly PCP. Furthermore, identification of a diffuse pattern may permit the use of a less invasive test more specifically directed at the confirmation of a diagnosis of PCP.

• Research Organization: New York Univ. Medical Center, NY (USA)
• OSTI ID: 6350920
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 170; ISSN RADLA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AIDS
ALGORITHMS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
BODY AREAS
CARBOXYLIC ACID SALTS
CHEST
CITRATES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM 67
GALLIUM ISOTOPES
HEMIC DISEASES
IMMUNE SYSTEM DISEASES
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MAN
MATHEMATICAL LOGIC
NUCLEI
ODD-EVEN NUCLEI
PATIENTS
PNEUMONIA
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM DISEASES
UPTAKE
VERTEBRATES
VIRAL DISEASES