Location of 64K collagen producer chondrocytes in developing chicken embryo tibiae

Journal Article · Fri Jun 01 04:00:00 EDT 1984 · Mol. Cell. Biol.; (United States)

DOI:https://doi.org/10.1128/MCB.4.6.1163· OSTI ID:6350108

Capasso, O; Tajana, G; Cancedda, R

The synthesis of a new low-molecular-weight collagen by cultured chicken embryo chondrocytes has been recently demonstrated. In this paper the authors report results on the location of chondrocytes synthesizing this new collagen (64K collagen) in the developing chicken embryo. The 64K collagen is synthesized in very large amounts by cells concentrated at the diaphysis of 9-day-old and at the epiphysis of 17-day-old embryo tibiae. These regions are characterized by a remodeling of the cartilage matrix leading to the replacement of the cartilage with bone tissue; therefore, this collagen appears to be a marker of a specific developmental stage of chondrocytes. The origin of cells competent for the synthesis of the 64K collagen is also discussed.

• Research Organization: Universita di Napoli, Italy
• OSTI ID: 6350108
• Journal Information: Mol. Cell. Biol.; (United States), Journal Name: Mol. Cell. Biol.; (United States) Vol. 4:6; ISSN MCEBD
• Country of Publication: United States
• Language: English

Related Subjects

550301* -- Cytology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
BIOLOGICAL LOCALIZATION
BIOSYNTHESIS
BIRDS
BODY
CARBOXYLIC ACIDS
CHICKENS
COLLAGEN
DRUGS
EMBRYONIC CELLS
FOWL
ISOTOPES
LIPOTROPIC FACTORS
METHIONINE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
SCLEROPROTEINS
SKELETON
SULFUR ISOTOPES
SYNTHESIS
TIBIA
VERTEBRATES