Influence of environmental pH on the interaction and repair of heat and radiation damage

Journal Article · Mon Jun 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(81)90470-3· OSTI ID:6341006

Freeman, M L; Boone, M L.M.; Ensley, B A; Gillette, E L

Madcap-37 cells derived from a mouse mammary tumor were heated and/or irradiated in vitro at pH 7.4 to 7.5 or 6.5 to 6.7. An acidic medium increased cytotoxicty resulting from hyperthermic treatment, but only after extended heating (e.g., 100 min at 42.5/sup 0/C). Cell lethality resulting from treatment by the combined modalities was also increased when the environmental pH was decreased. The increase in lethality was a result of an acidic environment increasing hyperthermic radiosensitization. The recovery from heat (60 min at 42.5/sup 0/C) and radiation (500 rad) damage was independent of environmental pH if the irradiation preceded heating. However, an acidic environment prolonged the duration of hyperthermic radiosensitization when heat preceded radiation.

• Research Organization: Colorado State Univ., Fort Collins
• OSTI ID: 6341006
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 7:6; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560121* -- Radiation Effects on Cells-- External Source-- (-1987)
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
BODY TEMPERATURE
CELL KILLING
DISEASES
DOSES
ENERGY
GLANDS
HEAT
HYPERTHERMIA
IN VITRO
MAMMARY GLANDS
NEOPLASMS
ORGANS
PH VALUE
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
TUMOR CELLS