Carcinoma of the vagina. [Complications following whole-pelvis. gamma. irradiation and radium implant therapy]

Journal Article · Wed Nov 01 04:00:00 EST 1978 · Cancer; (United States)

OSTI ID:6339297

Marcus, Jr, R B; Million, R R; Daly, J W

Twenty-two patients with Stage I through IV primary vaginal squamous cell carcinomas treated for cure with radiation therapy are reviewed, with particular emphasis on the relationship of dose to complications and local control. All but 2 patients received 4000 to 6000 rad whole pelvis irradiation plus at least one radium application. Local control was 91%, with an absolute 2-year disease-free survival of 82%. The degree of anaplasia was found to influence prognosis, with all local and distant failures resulting from high-grade lesions. The complication rate was modest, with no fistulae or serious bowel complications. An analysis of total dose (external plus radium) with respect to local failure and complications showed that no major complications occurred at a combined dose below 9000 rad. An analysis of the individual contributions of external irradiation and radium implants showed that all but one very minor complication occurred at a radium dose of 4000 rad or higher. From these data, overall treatment planning and total dose recommendations are made.

• Research Organization: Univ. of Florida, Gainesville
• OSTI ID: 6339297
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 42:5; ISSN CANCA
• Country of Publication: United States
• Language: English

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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ALPHA DECAY RADIOISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
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COBALT 60
COBALT ISOTOPES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELECTROMAGNETIC RADIATION
EVEN-EVEN NUCLEI
EXTERNAL IRRADIATION
FEMALE GENITALS
FIBROSIS
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEAVY NUCLEI
IMPLANTS
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
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LOCAL IRRADIATION
MALFORMATIONS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PELVIS
RADIATION EFFECTS
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOTHERAPY
RADIUM 224
RADIUM ISOTOPES
SIDE EFFECTS
THERAPY
URINARY TRACT
YEARS LIVING RADIOISOTOPES