Metronidazole and interstitial implantation in the treatment of extensive recurrent head and neck cancers. [/sup 192/Ir]

Journal Article · Wed Jul 01 04:00:00 EDT 1981 · Cancer; (United States)

OSTI ID:6337298

Orr, L E ^[1]; Puthawala, A; Nisar Syed, A M; Fleming, P A

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1. Southern California Cancer Center, Los Angeles

Twenty-three patients with recurrent or persistent epidermoid carcinoma of the oral cavity, all of whom had failed primary antitumor therapy, were treated with interstitial irradiation and a radio-sensitizer. All patients underwent afterloading interstitial iridium-192 implants. Each subject received 6 g/m/sup 2/ metronidazole administered orally in one dose every 48 hours for the duration of the implant. The radiation dose ranged between 4500 and 6500 rads in 65 to 120 hours. Sixteen of 23 patients (69.6%) demonstrated complete regression of local disease, usually within 12 weeks. Ten of the 23 individuals (43%) remain alive and disease-free with an average follow-up of 25 months since the completion of the regimen. Neurologic and hepatic toxicity were notably absent. Nausea, mild diarrhea and accentuation of the radiation-induced mucositis constituted the principal side effects.

• OSTI ID: 6337298
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 48:1; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603 -- Medicine-- External Radiation in Therapy-- (1980-)
560151* -- Radiation Effects on Animals-- Man
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
ANTINEOPLASTIC DRUGS
AZOLES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
CARCINOMAS
DAYS LIVING RADIOISOTOPES
DIARRHEA
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEAD
HEAVY NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
IMIDAZOLES
IMPLANTS
INJURIES
INTERNAL CONVERSION RADIOISOTOPES
IRIDIUM 192
IRIDIUM ISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LOCAL RADIATION EFFECTS
MEDICINE
MEMBRANES
METRONIDAZOLE
MINUTES LIVING RADIOISOTOPES
MUCOUS MEMBRANES
NAUSEA
NECK
NECROSIS
NEOPLASMS
NITRO COMPOUNDS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OSTEORADIONECROSIS
PATHOLOGICAL CHANGES
PATIENTS
RADIATION EFFECTS
RADIATION INJURIES
RADIATION SOURCE IMPLANTS
RADIATION SOURCES
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
SIDE EFFECTS
SKELETAL DISEASES
SYMPTOMS
THERAPY
YEARS LIVING RADIOISOTOPES