Detoxification of acetylcholinesterase inhibitors. Final report, 1 June 1984-30 November 1986
Technical Report
·
OSTI ID:6336097
The research support by ARO contract 21288-LS entitled Detoxification of acetylcholinesterase inhibitors resulted in the cloning and partial sequence of two opd genes from Pseudomonas diminuta and Flavobacterium species. It has been possible to isolate the enzyme in association with a small membrane fraction and initiate an evaluation of the organophosphate hydrolase. Collaborative interactions with research scientists at the Chemical Defense Research Command have suggested that the Pseudomonas species is competent to degrade selected types of biological neurotoxins.
- Research Organization:
- Texas A and M Univ., College Station (USA). Research Foundation
- OSTI ID:
- 6336097
- Report Number(s):
- AD-A-181142/1/XAB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
350000 -- Arms Control-- (1987-)
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANTIGENS
AUTONOMIC NERVOUS SYSTEM AGENTS
BACTERIA
CARBOXYLESTERASES
CHEMICAL WARFARE AGENTS
CHOLINESTERASE
CLONING
DETOXIFICATION
DRUGS
ENZYMES
ESTERASES
ESTERS
GENETIC ENGINEERING
HYDROLASES
MATERIALS
MICROORGANISMS
NEUROREGULATORS
ORGANIC COMPOUNDS
PARASYMPATHOMIMETICS
PSEUDOMONAS
QUATERNARY COMPOUNDS
TOXIC MATERIALS
TOXINS
WEAPONS
37 INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY
400201* -- Chemical & Physicochemical Properties
98 NUCLEAR DISARMAMENT, SAFEGUARDS, AND PHYSICAL PROTECTION
ACETYLCHOLINE
AMINES
AMMONIUM COMPOUNDS
ANTIGENS
AUTONOMIC NERVOUS SYSTEM AGENTS
BACTERIA
CARBOXYLESTERASES
CHEMICAL WARFARE AGENTS
CHOLINESTERASE
CLONING
DETOXIFICATION
DRUGS
ENZYMES
ESTERASES
ESTERS
GENETIC ENGINEERING
HYDROLASES
MATERIALS
MICROORGANISMS
NEUROREGULATORS
ORGANIC COMPOUNDS
PARASYMPATHOMIMETICS
PSEUDOMONAS
QUATERNARY COMPOUNDS
TOXIC MATERIALS
TOXINS
WEAPONS