Stimulation by epinephrine of the membrane transport of long chain fatty acid in the adipocyte
Journal Article
·
· J. Biol. Chem.; (United States)
OSTI ID:6335795
In isolated rat adipocytes, epinephrine rapidly stimulates the transport of long chain fatty acid across the plasma membrane. At a concentration of unbound oleate of 0.1 microM and 5 min exposure to the hormone, the minimal effective concentration of epinephrine is 0.03 and the optimal concentration 0.3 microM (0.01 and 0.1 microgram/ml). The stimulated rates are 5-10-fold the basal rate of influx or efflux. The hormone effect is on the transport process specifically as shown by isolation of the product of transport in either direction as unesterified fatty acid and inhibition by the transport inhibitors phloretin and 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid. This effect of epinephrine on transport coordinates physiologically with lipase activation to bring about fatty acid release from adipose tissue.
- Research Organization:
- Vanderbilt Univ. School of Medicine, Nashville, TN
- OSTI ID:
- 6335795
- Journal Information:
- J. Biol. Chem.; (United States), Journal Name: J. Biol. Chem.; (United States) Vol. 18; ISSN JBCHA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Uptake of oleate by isolated rat adipocytes is mediated by a 40-kDa plasma membrane fatty acid binding protein closely related to that in liver and gut
Triphenylmethylphosphonium cation distribution as a measure of hormone-induced alterations in white adipocyte membrane potential
Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes
Journal Article
·
Thu Dec 31 23:00:00 EST 1987
· Proc. Natl. Acad. Sci. U.S.A.; (United States)
·
OSTI ID:5983227
Triphenylmethylphosphonium cation distribution as a measure of hormone-induced alterations in white adipocyte membrane potential
Journal Article
·
Thu Dec 31 23:00:00 EST 1981
· J. Membr. Biol.; (United States)
·
OSTI ID:6710478
Apoptosis inhibitor of macrophage (AIM) diminishes lipid droplet-coating proteins leading to lipolysis in adipocytes
Journal Article
·
Fri Jun 08 00:00:00 EDT 2012
· Biochemical and Biophysical Research Communications
·
OSTI ID:22207882
Related Subjects
550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ADRENAL HORMONES
ADRENALINE
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CONNECTIVE TISSUE
DRUGS
HORMONES
IN VITRO
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE TRANSPORT
MONOCARBOXYLIC ACIDS
NEUROREGULATORS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES
59 BASIC BIOLOGICAL SCIENCES
ADIPOSE TISSUE
ADRENAL HORMONES
ADRENALINE
ANIMAL TISSUES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL EFFECTS
BODY
CARBOXYLIC ACIDS
CARDIOTONICS
CARDIOVASCULAR AGENTS
CONNECTIVE TISSUE
DRUGS
HORMONES
IN VITRO
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
MEMBRANE TRANSPORT
MONOCARBOXYLIC ACIDS
NEUROREGULATORS
OLEIC ACID
ORGANIC ACIDS
ORGANIC COMPOUNDS
RATS
RODENTS
STEROID HORMONES
SYMPATHOMIMETICS
TISSUES
TRACER TECHNIQUES
TRITIUM COMPOUNDS
VERTEBRATES