Characterization of a DNA sequence family in the Prader-Willi/Angelman syndrome chromosome region in 15q11-q13
Journal Article
·
· Genomics; (United States)
- Universitaetsklinikum Essen (Germany)
IR4-3R (D15S11) is an anonymous DNA sequence from human chromosome 15. Using YAC cloning and restriction enzyme analysis, the authors have found that IR4-3R detects five related DNA sequences, which are spread over 700 kb within the Prader-Willi/Angelman syndrome chromosome region in 15q11-q 13. The RsaI and StyI polymorphisms, which were described previously, are associated with the most proximal copy of IR4-3R and are in strong linkage disequilibrium. IR4-3R represents the third DNA sequence family that has been identified in 15q11-q13. 14 refs., 2 figs., 1 tab.
- OSTI ID:
- 6333053
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 16:1; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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