Drug-induced chimerism and prevention of graft-versus-host disease in lethally irradiated mice transplanted with rat bone marrow. [Gamma radiation]

Journal Article · Fri Dec 01 00:00:00 EST 1978 · Transplantation; (United States)

OSTI ID:6332916

Pierpaoli, W; Maestroni, G J.M.

L-5-hydroxytryptophan, haloperidol, and phentolamine were administered subcutaneously to groups of mice. Some groups were inoculated i.p. or i.v. with bone marrow cells. The mice were given a dose of 900 rad of whole-body gamma radiation. Observations were made on survival rate, reconstitution with rat hematopoietic tissue, and capacity to reject or accept skin grafts. Results indicate that the combination of drug-induced tolerance and a newly established preconditioning regimen that eliminated postradiation damage and mortality results in reduction in incidence or delay in onset of GVHD, successful bone marrow grafting, and induction of persistent rat chimerism. (HLW)

• Research Organization: Univ. of Zuerich, Switzerland
• OSTI ID: 6332916
• Journal Information: Transplantation; (United States), Vol. 26:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE MARROW CELLS
CHIMERAS
DRUGS
RADIOSENSITIVITY EFFECTS
GRAFT-HOST REACTION
BIOLOGICAL RADIATION EFFECTS
HYDROXYTRYPTOPHAN
GAMMA RADIATION
MICE
RATS
SURVIVAL TIME
TRANSPLANTS
AMINO ACIDS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
HYDROXY ACIDS
IONIZING RADIATIONS
MAMMALS
MOSAICISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOPROTECTIVE SUBSTANCES
RESPONSE MODIFYING FACTORS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals