Regeneration of the epidermis and basement membrane of the planarian Dugesia japonica after total-body x irradiation
Fresh-water planarians were studied to examine effects of x rays on regeneration of the epidermis and basement membrane. During early stages of regeneration, free rhabdite-forming cells were associated with the wound epidermis and recruited it. In later stages, however, a gradual degeneration occurred in the epidermis and cells undergoing epithelization decreased in number. Eventually epidermal cells on the wound surface appeared necrotic as evidenced by pyknotic nuclei and vacuolized dense cytoplasm. The entire basement membrane could not be reconstituted in any stage after wounding though its precursor-like material was secreted in the interspace between epidermis and parenchyma. Morphological changes in extracellular products and in the cells surrounding the products suggest that epidermal cells which have covered the wound surface synthesize precursors of the basement membrane. Possible factors of a characteristic perturbation in epithelization and basement membrane formation after total-body irradiation are discussed.
- Research Organization:
- Kanazawa Medical Univ., Japan
- OSTI ID:
- 6332897
- Journal Information:
- Radiat. Res.; (United States), Vol. 77:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BIOLOGICAL REGENERATION
BIOLOGICAL RADIATION EFFECTS
CONNECTIVE TISSUE
EPIDERMIS
PLANARIA
WHOLE-BODY IRRADIATION
WOUNDS
X RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
ELECTROMAGNETIC RADIATION
EPITHELIUM
EXTERNAL IRRADIATION
INJURIES
INVERTEBRATES
IONIZING RADIATIONS
IRRADIATION
ORGANS
PLATYHELMINTHS
RADIATION EFFECTS
RADIATIONS
RECOVERY
SKIN
TISSUES
TURBELLARIA
560154* - Radiation Effects on Animals- Basic Studies- (-1987)