N-isopropy(/sup 123/I)p-iodoamphetamine brain scans with single-photon emission tomagraphy: discordacne with transmission computed tomography

Journal Article · Wed Dec 01 04:00:00 EST 1982 · Radiology; (United States)

OSTI ID:6328511

Lee, R G; Hill, T C; Holman, B L; Clouse, M E

Transmission computed tomography (CT) brain scans were compared with N-isopropyl (/sup 123/I)-p-iodoamphetamine (IMP) single-photon emission computed tomography (SPECT) brain scans to determine if there was a correlation between morphology, as seen on CT, and cerebral perfusion changes detected by IMP SPECT. In 12 patients with acute stroke, four showed no discordance between the edema seen on CT and perfusion deficits seen on IMP SPECT; five had positive IMP scans while initial CT scans were negative and follow-up CT scans demonstrated edema in the region of perfusion deficit seen on the IMP scans; and in four patients, the average perfusion deficit was 2.3 times greater than the edema shown on CT at 2 cm above the canthal-meatal line. In nine control patients, there was a 2.3% difference in IMP activity between the right and left hemispheres. The 12 stroke patients showed 30.3% less IMP activity in the abnormal hemisphere compared with the normal side. Three patients, one with temporal lobe seizure, one with hemiballismus, and the third with idiopathic intention tumor, had 54% greater IMP activity on the side of movement or seizure than on the normal side. The discordance between IMP and CT scans was clearly demonstrated in cases in which CT showed no abnormality but IMP provided information on function, reflected in increased or decreased cerebral perfusion.

• Research Organization: Department of Radiology, New England Deaconess Hospital, Boston, MA
• OSTI ID: 6328511
• Journal Information: Radiology; (United States), Journal Name: Radiology; (United States) Vol. 145:3; ISSN RADLA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
AMINES
AUTONOMIC NERVOUS SYSTEM AGENTS
BENZEDRINE
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
CEREBRUM
COMPARATIVE EVALUATIONS
COMPUTERIZED TOMOGRAPHY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DIAGNOSTIC USES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE 123
IODINE ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGY
PATIENTS
RADIOISOTOPES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
SYMPATHOMIMETICS
TOMOGRAPHY
USES
VASCULAR DISEASES