Photochemical reactions of biologically important quinoxaline n-oxides
The authors study the photochemical reactions of quinoxidine, dioxidine, and a number of related derivatives of quinoxaline 1,4-di-N-oxides containing methyl, halomethyl, and carboxamide groups in the pyrazine ring. Thin-layer chromatography, UV spectrophotometry, and NMR/sup 1/H and /sup 13/C spectroscopy were used as the main methods for monitoring the photolysis process and establishing the structure of the products formed. The investigation established that two types of photochemical reactions are observed in the series of compounds discussed: photoisomerization with migration of a substitutent to the nitrogen atom of the heterocycle, and photorearrangement with elimination of a substituent and the formation of the corresponding lactams.
- Research Organization:
- S. Ordzhonikidze All-Union Chemicopharmaceutical Scientific-Research Institute, Moscow (USSR)
- OSTI ID:
- 6326966
- Journal Information:
- Pharmaceut. Chem. J.; (United States), Journal Name: Pharmaceut. Chem. J.; (United States) Vol. 20:4; ISSN PCJOA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400500 -- Photochemistry
550200* -- Biochemistry
59 BASIC BIOLOGICAL SCIENCES
640302 -- Atomic
Molecular & Chemical Physics-- Atomic & Molecular Properties & Theory
74 ATOMIC AND MOLECULAR PHYSICS
AMIDES
ANTI-INFECTIVE AGENTS
AROMATICS
BIOCHEMISTRY
CARBON 13
CARBON ISOTOPES
CHALCOGENIDES
CHEMICAL REACTIONS
CHEMICAL SHIFT
CHEMISTRY
CHROMATOGRAPHY
COUPLING
COUPLING CONSTANTS
DRUGS
EVEN-ODD NUCLEI
HETEROCYCLIC COMPOUNDS
HYDROGEN 1
HYDROGEN ISOTOPES
HYPERFINE STRUCTURE
INTERMEDIATE COUPLING
ISOMERIZATION
ISOTOPES
J-J COUPLING
LACTAMS
LIGHT NUCLEI
MATERIALS TESTING
NMR SPECTRA
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PHARMACOLOGY
PHOTOCHEMICAL REACTIONS
SEPARATION PROCESSES
SPECTRA
STABLE ISOTOPES
SYNTHESIS
TESTING
THIN-LAYER CHROMATOGRAPHY
ULTRAVIOLET SPECTRA