Changes in the absorption of bile acids after total colectomy in patients with an ileostomy or pouch-anal anastomosis

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Dis. Colon Rectum; (United States)

DOI:https://doi.org/10.1007/BF02554535· OSTI ID:6326806

Nasmyth, D G; Johnston, D; Williams, N S; King, R F; Burkinshaw, L; Brooks, K

Bile acid absorption was investigated using /sup 75/Se Taurohomocholate (SeHCAT) in controls and patients who had undergone total colectomy with either conventional ileostomy or pouch-anal anastomosis for ulcerative colitis or adenomatous polyposis. Whole-body retention of SeHCAT after 168 hours was greater in the controls than the patients who had undergone colectomy (P less than .05). Retention of SeHCAT did not differ significantly between patients with an ileostomy and patients with pouch-anal anastomosis, but patients with an ileostomy and ileal resection of more than 20 cm retained less SeHCAT than patients with a pouch-anal anastomosis (P less than .01). Analysis of fecal bile acids from ileostomies and pouches showed that bacterial metabolism of primary conjugated bile acids was greater in patients with a pouch. It was concluded that bile acid absorption was not significantly impaired by construction of a pouch compared with conventional ileostomy, but bacterial metabolism of bile acids was greater in the pouches.

• Research Organization: Univ. Department of Surgery, Leeds (England)
• OSTI ID: 6326806
• Journal Information: Dis. Colon Rectum; (United States), Journal Name: Dis. Colon Rectum; (United States) Vol. 32:3; ISSN DICRA
• Country of Publication: United States
• Language: English

Related Subjects

550501* -- Metabolism-- Tracer Techniques
550901 -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ABSORPTION
BETA DECAY RADIOISOTOPES
BILE ACIDS
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
CARBOXYLIC ACIDS
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
FECES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
ISOTOPES
MATERIALS
MEDICINE
METABOLISM
NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PATIENTS
RADIOISOTOPES
SELENIUM 75
SELENIUM ISOTOPES
STEROIDS
STEROLS
SURGERY
TRACER TECHNIQUES
UPTAKE
WASTES