Radiosensitizing activity of 1-alkyl-3-nitropyrrolo-(2,3-b)-pyridine derivative
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
OSTI ID:6324674
Radiosensitization characteristics of a newly synthesized N-(3,N'-morpholinpropyl)-2-(3-nitropyrrolo-(2,3-b)-pyridine -1-yl) ethanoic acid amide and the chemical basis of the action were studied. Partition coefficient, redox potentials for the one electron reduction of the compound were determined. This was confirmed by studies on the radiosensitization effect and cytotoxicity of the compound tested in vitro using Chinese hamster V79 cells. The results show that the sensitizing efficiency for this compound is C1.6 at a concentration of 0.5 mmol dm-3, which is similar to MISO. Its toxicity was not lower than that of MISO or metronidazole.
- Research Organization:
- Shanghai Medical Univ. (China)
- OSTI ID:
- 6324674
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 16:2; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
AMINES
ANIMAL CELLS
ANIMALS
AZINES
BODY
DRUGS
ETHERS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IN VITRO
LUNGS
MAMMALS
MORPHOLINES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRIDINES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
REDOX POTENTIAL
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMIDES
AMINES
ANIMAL CELLS
ANIMALS
AZINES
BODY
DRUGS
ETHERS
HAMSTERS
HETEROCYCLIC COMPOUNDS
IN VITRO
LUNGS
MAMMALS
MORPHOLINES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRIDINES
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
REDOX POTENTIAL
RESPIRATORY SYSTEM
RODENTS
TOXICITY
VERTEBRATES