Synthesis and biological activity of gem-dichlorocyclopropyl ethers

Journal Article · Mon Sep 01 00:00:00 EDT 1986 · Pharmaceut. Chem. J.; (United States)

OSTI ID:6324220

Shostakovskii, S M; Mochalov, V N; Larionov, G M

In order to examine the antimicrobial activity of oxygenated cyclopropanes, the authors have synthesized the bis-gem-dichlorocyclopropyl ether of ethylene glycol, the meso- and dl- forms of bis-gem-dichlorocyclopropyl ether, and the gem-dichlorocyclopropyl alkyl ethers. The physiocochemical properties of compounds obtained are presented. The authors conclude that in the case of gem-dichlorocyclopropane compounds, decontamination of microorganisms occurs at the pre-metabolic stage, and results in the denaturation of the protein components of the cell wall and external membranes and of the specific peptides of the peptide-glycan layer.

• Research Organization: All-Union Research Institute for Organic Synthesis, Moscow (USSR)
• OSTI ID: 6324220
• Journal Information: Pharmaceut. Chem. J.; (United States), Vol. 19:11; Other Information: Translated from Khimiko-Farmatsevticheski Zhurnal; 19: No. 11, 1330-1335(Nov 1985)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMICROBIAL AGENTS
BIOLOGICAL EFFECTS
NMR SPECTRA
SYNTHESIS
TOXICITY
ETHERS
BACTERIA
CHEMICAL SHIFT
CHLORINATED ALIPHATIC HYDROCARBONS
CYCLOALKANES
DOSE-RESPONSE RELATIONSHIPS
FUNGI
GLYCOLS
INFRARED SPECTRA
MULTIPLETS
PATHOGENS
ALCOHOLS
ALKANES
ANTI-INFECTIVE AGENTS
DRUGS
HALOGENATED ALIPHATIC HYDROCARBONS
HYDROCARBONS
HYDROXY COMPOUNDS
MICROORGANISMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PLANTS
SPECTRA
550700* - Microbiology
560300 - Chemicals Metabolism & Toxicology
550500 - Metabolism