The investigation of molecular mechanisms in photodynamic action and radiobiology with nanosecond flash photolysis and pulse radiolysis: Final report for period April 1, 1972-June 30, 1987
Technical Report
·
OSTI ID:6323299
Laser flash was employed to investigate initial photolysis mechanisms in enzymes and constituent aromatic amino acids. The key role of photoionization and solvated electron generation was demonstrated. The photochemistry of furocoumarins employed for phototherapy of skin diseases was investigated, emphasizing the production and subsequent reactions of singlet molecular oxygen. The photochemistry of porphyrins employed for photodynamic therapy of malignant tumors was studied, emphasizing photosensitization of model membranes, liposomes and resealed red blood cell membranes. Photosensitization in light-scattering media was investigated in a tissue model, consisting of polystyrene microspheres in an aqueous dye solution and analyzed with the diffusion approximation to radiative transfer. The diffusion approximation was employed to develop a dosimetry model for photodynamic therapy.
- Research Organization:
- Illinois Inst. of Tech., Chicago (USA)
- DOE Contract Number:
- AC02-76EV02217
- OSTI ID:
- 6323299
- Report Number(s):
- DOE/EV/02217-58; ON: DE87013685
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANTICOAGULANTS
AROMATICS
AZAARENES
AZOLES
CARBOXYLIC ACIDS
CARBOXYPEPTIDASES
CELL CONSTITUENTS
CHEMICAL REACTIONS
COUMARINS
DECOMPOSITION
DRUGS
ENZYMES
GLYCOSYL HYDROLASES
HEMATOLOGIC AGENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
HYDROXY ACIDS
INDOLES
LASERS
LIPOSOMES
LYSOZYME
O-GLYCOSYL HYDROLASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
PEPTIDE HYDROLASES
PHOTOCHEMICAL REACTIONS
PHOTOLYSIS
PHOTOSENSITIVITY
PORPHYRINS
PSORALEN
PYRROLES
SENSITIVITY
TRYPTOPHAN
TYROSINE
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANTICOAGULANTS
AROMATICS
AZAARENES
AZOLES
CARBOXYLIC ACIDS
CARBOXYPEPTIDASES
CELL CONSTITUENTS
CHEMICAL REACTIONS
COUMARINS
DECOMPOSITION
DRUGS
ENZYMES
GLYCOSYL HYDROLASES
HEMATOLOGIC AGENTS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROLASES
HYDROXY ACIDS
INDOLES
LASERS
LIPOSOMES
LYSOZYME
O-GLYCOSYL HYDROLASES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANOIDS
PEPTIDE HYDROLASES
PHOTOCHEMICAL REACTIONS
PHOTOLYSIS
PHOTOSENSITIVITY
PORPHYRINS
PSORALEN
PYRROLES
SENSITIVITY
TRYPTOPHAN
TYROSINE