Early Indium-111 antimyosin scintigraphy for assessment of regional wall motion asynergy on discharge after myocardial infarction

Journal Article · Mon Jan 01 00:00:00 EST 1990 · International Journal of Cardiac Imaging; (USA)

DOI:https://doi.org/10.1007/BF01797841· OSTI ID:6323105

van Vlies, B; Baas, J; Visser, C A; van Royen, E; Delemarre, B J; Bot, H; Dunning, A J ^[1]

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1. Academic Medical Center, Amsterdam (Netherlands)

To assess the relation between early Indium-111 monoclonal antimyosin antibody scintigraphy and degree of regional asynergy on discharge, 38 patients with a first acute myocardial infarct were studied (18 anterior, 20 inferoposterior infarctions). In 21 patients thrombolytic therapy was administered. On the first day of myocardial infarction, 80 MBq Indium-111 Antimyosin was injected. Planar images, anterior, lateral and left anterior oblique, were made 24 hours later. Localized myocardial uptake was present in 37/38 patients, and was evaluated for Count Density Index (count density of infarct zone/left lung count density) in the left anterior oblique images, which displayed the infarct zone well. Regional asynergy on discharge was evaluated by cross-sectional echocardiography and defined mild (hypokinesia) or severe (akinesia or dyskinesia). Count density index was significantly lower in 15 patients with mild asynergy, compared with 22 patients with severe asynergy (1.61 +/- 0.25 vs. 2.42 +/- 0.40, p less than 0.001). This difference was present in both patient groups treated with or without thrombolysis. We conclude that early count density index, reflecting the amount of local necrosis, is highly correlated to the ultimate degree of wall motion impairment.

• OSTI ID: 6323105
• Journal Information: International Journal of Cardiac Imaging; (USA), Vol. 5:4; ISSN 0167-9899
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
CARDIOVASCULAR DISEASES
DIAGNOSIS
HEART
RADIOIMMUNOSCINTIGRAPHY
INDIUM 111
MONOCLONAL ANTIBODIES
MYOCARDIAL INFARCTION
MYOSIN
PATIENTS
ANTIBODIES
BETA DECAY RADIOISOTOPES
BODY
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COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLOBULINS
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOIMMUNODETECTION
RADIOISOTOPE SCANNING
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550601* - Medicine- Unsealed Radionuclides in Diagnostics