Combined effects of ozone and nitrogen dioxide on respiratory function in man
Ten young adult males were exposed to either filtered air or 0.50 ppM ozone plus 0.50 ppM NO/sub 2/ in filtered air under four environmental conditions: 25/sup 0/C, 45% rh; 30/sup 0/C, 85% rh; 35/sup 0/C, 40% rh; and 40/sup 0/C, 50% rh. There were eight 2-hour exposures per subject. After 1 hour of sitting exposure the subjects exercised for 30 minutes which increased ventilatory exchange to approximately 40 L/min. Pulmonary function tests were performed before, during, and after exposure. Metabolism and ventilation were determined during the last 15 minutes of exercise. A symptom questionnaire was completed at the termination of each exposure following reexamination by a physician. There was a decrease in vital capacity, inspiratory capacity, and several flow-related measures of lung function during exposure. The response to exposure to the combined pollutants was similar to that observed in ozone exposures alone. No synergism was observed.
- Research Organization:
- Univ. of California, Santa Barbara
- OSTI ID:
- 6317364
- Journal Information:
- Am. Ind. Hyg. Assoc. J.; (United States), Journal Name: Am. Ind. Hyg. Assoc. J.; (United States) Vol. 42:7; ISSN AIHAA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
BODY
CHALCOGENIDES
DOSE-RESPONSE RELATIONSHIPS
EXERCISE
INHALATION
INTAKE
LUNGS
MEDICAL SURVEILLANCE
METABOLISM
NITROGEN COMPOUNDS
NITROGEN DIOXIDE
NITROGEN OXIDES
ORGANS
OXIDES
OXYGEN COMPOUNDS
OZONE
PATIENTS
RESPIRATION
RESPIRATORY SYSTEM
SENSITIVITY
SURVEILLANCE
SYMPTOMS
TIME DEPENDENCE
VENTILATION