Effects of nickel sulfate, lead sulfate, and sodium arsenite alone and with UV light on sister chromatid exchanges in cultured human lymphocytes
Journal Article
·
· Molecular Toxicology; (USA)
OSTI ID:6314887
- New York Univ. Medical Center, NY (USA)
Sister chromatid exchanges (SCE) have been examined in human lymphocytes following in vitro treatments with metal salts, nickel sulfate, lead sulfate and sodium arsenite. All of the metal salts produced significant increases in the SCE frequencies over the levels for untreated lymphocytes. The SCE frequencies were also examined for metal treatments combined with ultraviolet light (200 ergs/mm2). For the lead treatments combined with the UV dose selected, an additive SCE response was observed compared to the SCE responses for UV or metal alone. The nickel and arsenite treatments combined with UV produced a less than additive SCE response for most concentrations tested. These results suggest that nickel or arsenite present in complex mixtures may reduce the SCE response to other compounds in the mixture normally capable of producing a much stronger SCE response and therefore lead to an underestimate of the effects of chemical exposure.
- OSTI ID:
- 6314887
- Journal Information:
- Molecular Toxicology; (USA), Journal Name: Molecular Toxicology; (USA) Vol. 2:2; ISSN 0883-9492; ISSN MOTOE
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560120 -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ARSENIC
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ELEMENTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
LEAD
LEUKOCYTES
LYMPHOCYTES
MATERIALS
METALS
MUTATION FREQUENCY
MUTATIONS
NICKEL
RADIATION EFFECTS
RADIATIONS
SEMIMETALS
SENSITIVITY
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
SYNERGISM
TRANSITION ELEMENTS
ULTRAVIOLET RADIATION
Cells
& Tissue Culture
560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ARSENIC
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BLOOD
BLOOD CELLS
BODY FLUIDS
CHROMOSOMAL ABERRATIONS
CONNECTIVE TISSUE CELLS
ELECTROMAGNETIC RADIATION
ELEMENTS
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
LEAD
LEUKOCYTES
LYMPHOCYTES
MATERIALS
METALS
MUTATION FREQUENCY
MUTATIONS
NICKEL
RADIATION EFFECTS
RADIATIONS
SEMIMETALS
SENSITIVITY
SISTER CHROMATID EXCHANGES
SOMATIC CELLS
SYNERGISM
TRANSITION ELEMENTS
ULTRAVIOLET RADIATION