Positron emission tomographic studies of aging and Alzheimer disease

Journal Article · · AJNR, Am. J. Neuroradiol.; (United States)

OSTI ID:6306262

de Leon, M J; Ferris, S H; George, A E; Christman, D R; Fowler, J S; Gentes, C; Reisberg, B; Gee, B; Emmerich, M; Yonekura, Y

The positron emission tomographic (PET)-/sup 18/F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.

• Research Organization: New York Univ. Medical Center, NY
• OSTI ID: 6306262
• Journal Information: AJNR, Am. J. Neuroradiol.; (United States), Journal Name: AJNR, Am. J. Neuroradiol.; (United States) Vol. 4; ISSN AAJND
• Country of Publication: United States
• Language: English

Related Subjects

550900* -- Pathology
59 BASIC BIOLOGICAL SCIENCES
ALDEHYDES
ANIMALS
BODY
BRAIN
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
CORRELATIONS
DETECTION
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
GLUCOSE
HEXOSES
LIFE SPAN
MAMMALS
MAN
METABOLIC DISEASES
METABOLISM
MONOSACCHARIDES
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
POSITRON COMPUTED TOMOGRAPHY
PRIMATES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES