Dose-response relationships for radium-induced bone sarcomas

Conference · Thu Jan 01 04:00:00 EST 1981

OSTI ID:6300424

Rowland, R E; Stehney, A F; Lucas, Jr, H F

The incidence of bone sarcomas among 3055 female radium-dial workers who entered the dial industry before 1950 was used to determine dose-response relationships for the induction of bone sarcomas by radium. Two subpopulations were analyzed: all measured cases who survived at last five years after the start of employment and all cases who survived at least two years after first measurement. The first constituted a group based on year of entry; it contained 1468 women who experienced 42 bone sarcomas; the expected number was 0.4. The second comprised a group based on first measurement; it contained 1257 women who experienced 13 bone sarcomas; the expected number was 0.2. The dose-response function, I = (C + ..cap alpha..D + ..beta..D/sup 2/)e/sup -..gamma..D/, and simplifications of this general form, were fit to each data set. Two functions, I = (C + ..cap alpha..D + ..beta..D/sup 2/)e/sup -..gamma..D/ and I = (C + ..beta..D/sup 2/)e/sup -..gamma..D/, fit the data for year of entry (p greater than or equal to 0.05); both these functions and I = (C + ..cap alpha..D) fit the data for first measurement. The function I = (C + ..beta..D/sup 2/)e/sup -..gamma..D/ was used to predict the number of bone sarcomas in all other pre-1950 radium cases (medical, laboratory, and other exposure); fewer were actually observed than the fit of this function to the female dial workers predicted.

• Research Organization: Argonne National Lab., IL (USA)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 6300424
• Report Number(s): CONF-8110126-9; ON: DE83010703
• Country of Publication: United States
• Language: English

Related Subjects

560161* -- Radionuclide Effects
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH METALS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DATA
DELAYED RADIATION EFFECTS
DIAL PAINTERS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EXPERIMENTAL DATA
FEMALES
INFORMATION
MAMMALS
MAN
METALS
NEOPLASMS
NUMERICAL DATA
PERSONNEL
PRIMATES
RADIATION EFFECTS
RADIOINDUCTION
RADIUM
SARCOMAS
SURVIVAL TIME
VERTEBRATES
WOMEN