Peptide F (pro-enkephalin fragment): radioimmunoassay, and stress-induced changes in adrenal
Journal Article
·
· Life Sci.; (United States)
- Mental Health Research Inst., Ann Arbor, MI
Utilizing a nine amino-acid (Asp-Glu-Leu-Tyr-Pro-Leu-Glu-Val-Glu) non-enkephalin containing fragment of Peptide F from the pro-enkephalin molecule, a radioimmunoassay was developed. Extraction of bovine, rat, and guinea pig adrenomedullary preparations demonstrated this fragment to be present and apparently partially conserved across species. In rats, acute inescapable foot-shock stress led to a significant decrease of the immunoreactive material in the adrenal medulla. Chronic daily stress for two weeks resulted in an inability of the adrenals to alter F levels upon subsequent stress. The existence of F-like immunoreactivity and its alteration by environmental manipulation, suggest that it may play a unique physiological role.
- OSTI ID:
- 6299100
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 31:16-17; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
Novel human growth hormone like protein HGH-V encoded in the human genome
Radioimmunoassay and characterization of enkephalins in rat tissues
Covalent structure of apolipoprotein A-II from Macaca mulatta serum high-density lipoproteins. [Apolipoprotein]
Patent
·
Tue May 12 00:00:00 EDT 1987
·
OSTI ID:6409756
Radioimmunoassay and characterization of enkephalins in rat tissues
Journal Article
·
Tue Jan 24 23:00:00 EST 1978
· J. Biol. Chem.; (United States)
·
OSTI ID:6934508
Covalent structure of apolipoprotein A-II from Macaca mulatta serum high-density lipoproteins. [Apolipoprotein]
Journal Article
·
Mon Mar 22 23:00:00 EST 1976
· Biochemistry; (United States)
·
OSTI ID:7187547
Related Subjects
550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL ADAPTATION
BIOLOGICAL STRESS
BODY
CATTLE
CHRONIC EXPOSURE
DOMESTIC ANIMALS
DRUGS
ENDOCRINE GLANDS
ENDORPHINS
ENKEPHALINS
GLANDS
GUINEA PIGS
IMMUNE REACTIONS
ISOTOPE APPLICATIONS
MAMMALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RATS
RODENTS
RUMINANTS
TRACER TECHNIQUES
VERTEBRATES
62 RADIOLOGY AND NUCLEAR MEDICINE
ADRENAL GLANDS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOLOGICAL ADAPTATION
BIOLOGICAL STRESS
BODY
CATTLE
CHRONIC EXPOSURE
DOMESTIC ANIMALS
DRUGS
ENDOCRINE GLANDS
ENDORPHINS
ENKEPHALINS
GLANDS
GUINEA PIGS
IMMUNE REACTIONS
ISOTOPE APPLICATIONS
MAMMALS
NEUROREGULATORS
ORGANIC COMPOUNDS
ORGANS
PEPTIDES
POLYPEPTIDES
PROTEINS
RADIOASSAY
RADIOIMMUNOASSAY
RATS
RODENTS
RUMINANTS
TRACER TECHNIQUES
VERTEBRATES