Control of radiation-induced emesis with promethazine, cimetidine, thiethylperazine, or naloxone. [/sup 60/Co]

Journal Article · Wed Aug 01 04:00:00 EDT 1979 · Am. J. Vet. Res.; (United States)

OSTI ID:6297123

Cooper, J R; Mattsson, J L

Promethazine (2 mg/kg), cimetidine (4 mg;kg), thiethylperazine (0.86 mg/kg), and naloxone (0.08 mg/kg) were each evaluated for their ability to increase the threshold of radiation-induced emesis in the dog. Each dog was fed a can of dog food (ca 0.4 kg) and then injected IM with the appropriate drug 1 hour before being irradiated by a /sup 60/Co teletherapy unit. Dogs were then observed continuously for 10 hours while the number, time of onset, and duration of each emetic episode were monitored. The dose of radiation causing emesis in 50% control dogs was 170 rad. The ED50 was increased to 402 rad by promethazine, to 331 rad by cimetidiene, and to 320 rad by thiethylperazine. The ED50 for naloxone was 262.5 rad, which was not a statistically significant increase in threshold.

• Research Organization: School of Aerospace Medicine, Brooks Air Force Base, TX
• OSTI ID: 6297123
• Journal Information: Am. J. Vet. Res.; (United States), Journal Name: Am. J. Vet. Res.; (United States) Vol. 40:8; ISSN AJVRA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANTIHISTAMINICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
COBALT 60
COBALT ISOTOPES
DOGS
DRUGS
ELECTROMAGNETIC RADIATION
GAMMA RADIATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
PROMETHAZINE
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
RADIOSENSITIVITY EFFECTS
SYMPTOMS
VERTEBRATES
VOMITING
YEARS LIVING RADIOISOTOPES