Chronic effects of JP-8 jet fuel exposure on the lungs. Annual technical report, 1 April 1992-1 April 1993

Technical Report · Tue Apr 13 04:00:00 EDT 1993

OSTI ID:6296028

Witten, M L

The second year of this project concentrated on using a high dose of JP-8 jet fuel in our exposure regimen. We selected a target dose of approximately 1,000 mg/m3 based on a published epidemiological study conducted at NATO Air Force Bases that demonstrated jet fuel concentrations as high as 1,020 mg/m3 during refueling operations. The rats in the high dose studies were exposed to an average of 813.8 Mg/m 3 for one hour/day for 7 and 28 days. In our previous work, a low dose concentration of JP-8 jet fuel (500 mg/m3) for one hour/day for 7 and 28 days did not show any significant changes in lung structures by light microscopy. However, when light microscopy was performed on lung sections from rats exposed to JP-8 jet fuel for 7 and 28 days at the high dose concentration, the evidence for injury to the alveolar-capillary barrier was overwhelming. In these rats, we observed red blood cells in the alevolar air spaces, distortion of the bronchial airways, and loss of epithelial cells in the alveoli. These findings were substantiated by electron microscopy which showed epithelial cells missing their basement membrane, airways devoid of cilia, and alterations of type II alveolar epithelial cells.

• Research Organization: Arizona Univ., Tucson, AZ (United States)
• OSTI ID: 6296028
• Report Number(s): AD-A-264162/9/XAB; CNN: AFOSR-91-0199
• Country of Publication: United States
• Language: English

Related Subjects

02 PETROLEUM
020900* -- Petroleum-- Environmental Aspects
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINES
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CHANNELING
DATA
DIGESTIVE SYSTEM
ELECTRON MICROSCOPY
ENZYMES
EPIDEMIOLOGY
FUELS
FUNCTIONS
GLANDS
HETEROCYCLIC COMPOUNDS
HISTAMINE
HYDROCARBONS
IMIDAZOLES
INFORMATION
INJURIES
INTERNATIONAL ORGANIZATIONS
JET ENGINE FUELS
KIDNEYS
LIVER
LUNGS
MAMMALS
MATERIALS
MEMBRANES
MICE
MICROSCOPY
NATIONAL ORGANIZATIONS
NATO
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PERMEABILITY
PROTEINS
RATS
RESEARCH PROGRAMS
RESPIRATORY SYSTEM
RODENTS
SENSITIVITY
SPLEEN
STATISTICAL DATA
TOXICITY
US DOD
US ORGANIZATIONS
VERTEBRATES
WOUNDS