Oxygen enhancement ratio as a function of neutron energy with mammalian cells in culture

Technical Report · Mon Jan 01 04:00:00 EST 1979

DOI:https://doi.org/10.2172/6294638· OSTI ID:6294638

Rini, F J; Hall, E J; Marino, S A

Chinese hamster cells (V79) in culture under oxic and hypoxic conditions were irradiated with several neutron beams spanning a wide energy range. Eight essentially monoenergetic neutron beams, ranging from 0.22 to 13.6 MeV and a 0.11 MeV neutron spectrum, were produced at the Radiological Research Accelerator Facility (RARAF) at Brookhaven National Laboratory. Additional experiments were performed at the Naval Research Laboratory, Washington, D.C., where neutrons are produced for radiotherapy by bombarding a beryllium target with 35 MeV deuterons. This beam has a broad energy spectrum with a mean energy of about 15 MeV. A maximum OER of about 1.9 was observed for 13.6 MeV neutrons. The OER values of the monoenergetic neutrons decreased with neutron energy, plateaued at about 1.45 for the energy range from 0.22 to 2.0 MeV and increased slightly to about 1.55 for lower energy spectrum. In the light of microdosimetric data obtained for the neutron beams at RARAF, the OER appears to depend primarily on the intermediate LET secondaries produced by neutrons in tissue, such as protons, while in contrast high LET secondaries, such as, alpha particles and recoil ions, play a minor role. The studies using the NRL neutron beam resulted in a lower OER of about 1.67 as compared to the monoenergetic 13.6 MeV beam.

• Research Organization: Columbia Univ., New York (USA). Coll. of Physicians and Surgeons
• DOE Contract Number: EP-78-S-02-4733
• OSTI ID: 6294638
• Report Number(s): COO-4733-T1
• Country of Publication: United States
• Language: English

Related Subjects

560121* -- Radiation Effects on Cells-- External Source-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BARYONS
BEAMS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BNL
CELL CULTURES
CRYOGENIC FLUIDS
DATA
DATA FORMS
DOSES
DOSIMETRY
ELEMENTARY PARTICLES
ELEMENTS
ENERGY SPECTRA
ENERGY TRANSFER
EXPERIMENTAL DATA
FERMIONS
FLUIDS
GRAPHS
HADRONS
INFORMATION
ISOLATED VALUES
LET
MICRODOSIMETRY
NATIONAL ORGANIZATIONS
NEUTRON BEAMS
NEUTRONS
NONMETALS
NUCLEON BEAMS
NUCLEONS
NUMERICAL DATA
ORES
OXYGEN
PARTICLE BEAMS
RADIATION DOSES
RADIATION EFFECTS
SPECTRA
US AEC
US DOE
US ERDA
US ORGANIZATIONS