Delayed complications in colo-rectal carcinoma treated by combination radiotherapy and 5-fluorouracil: Eastern Cooperative Oncology Group (E. C. O. G. ) pilot study. [/sup 60/Co-teletherapy]
From June 1976 to Dec 1977, 24 patients with residual, or recurrent, inoperable rectal carcinoma, were treated by a split-course irradiation and 5-FU. All patients received /sup 60/Co pelvic irradiation, with AP--PA opposed fields. The dose was delivered in 3 courses of 2000 rad in 2 weeks, with 2 weeks rest between each course. 5 Fluorouracil (5-FU)-(500 mg/m/sup 2/), was administered I.V., on the first 3 days of each course of irradiation. The acute reaction was minimal, and was not predictive of the late serious complications which occurred in 7/24 (29%), of our patients, 2/10 with minimal, and 5/14 with bulky pelvic disease. The median follow-up was 12 months--(range 4 to 26 months). The onset of serious complications occurred about 8 months following treatment, and consisted of bowel stenosis, necrosis, fistula formation, and subcutaneous fibrosis. In 5 of 7 patients, predisposing factors accounted for such complications. We believe this to be the first report of such an observation of delayed complications in the absence of serious early reaction with combined chemoradiotherapy. The safety of multimodality therapy cannot be predicted by how well it is tolerated initially.
- Research Organization:
- Ontario Cancer Foundation, Ottawa, Canada
- OSTI ID:
- 6294367
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:3; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIMETABOLITES
ANTIMITOTIC DRUGS
AZINES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BLADDER
BODY
BODY AREAS
CARCINOMAS
CHEMOTHERAPY
COBALT 60
COBALT ISOTOPES
DELAYED RADIATION EFFECTS
DIARRHEA
DIGESTIVE SYSTEM
DISEASES
DRUGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
FIBROSIS
FISTULAE
FLUOROURACILS
FRACTIONATED IRRADIATION
GAMMA RADIATION
GASTROINTESTINAL TRACT
HEMORRHAGE
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INFLAMMATION
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
INTESTINES
IONIZING RADIATIONS
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LARGE INTESTINE
MALFORMATIONS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NECROSIS
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARTIAL BODY IRRADIATION
PATHOLOGICAL CHANGES
PATIENTS
PELVIS
PYRIMIDINES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOTHERAPY
RECTUM
SIDE EFFECTS
SKIN
SYMPTOMS
THERAPY
URACILS
URINARY TRACT
YEARS LIVING RADIOISOTOPES