Experimental radiation pneumonitis. III. Phospholipid studies on the lungs. [X radiation, mice]

Journal Article · Sun Apr 01 04:00:00 EST 1979 · J. Lab. Clin. Med.; (United States)

OSTI ID:6293927

Gross, N J

Mice received 2400 rads in two fractions to the thorax; 4 months later when radiation pneumonitis occurred, aspects of their phospholipid metabolism were studied and compared to those of unirradiated mice. In the lung tissue there was a consistent and significant increase in the total phospholipids and particularly in the amount of PC. The proportion of the latter which was disaturated remained constant. In the lavaged AF the increase was smaller and not significant, the degree of disaturation again remaining constant. Isotope labeling in vivo with /sup 3/H-glycerol, /sup 14/C-palmitate, and /sup 3/H-choline indicated significantly increased incorporation of each of these precursors into PC and most other phospholipids. This was not due to changes in nutrition, altered precursor pool size, or redistribution of isotope insofar as could be determined. Histologic studies showed the type 2 cells to be large and filled with numerous enlarged lamellar bodies. These results suggest that phospholipid synthesis is enhanced in radiation pneumonitis and that the fall in compliance of the alveolar surface layer is not likely to be due to surfactant deficiency in this model.

• Research Organization: Veterans Administration Hospital, Hines, IL
• OSTI ID: 6293927
• Journal Information: J. Lab. Clin. Med.; (United States), Journal Name: J. Lab. Clin. Med.; (United States) Vol. 93:4; ISSN JLCMA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DATA
DATA FORMS
ELECTROMAGNETIC RADIATION
ESTERS
EXPERIMENTAL DATA
INFORMATION
IONIZING RADIATIONS
ISOLATED VALUES
LIPIDS
LUNGS
MAMMALS
METABOLISM
MICE
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHOLIPIDS
PNEUMONITIS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
X RADIATION