Nitrous oxide-induced hypothermia in the rat

Journal Article · Mon Aug 10 04:00:00 EDT 1987 · Life Sci.; (United States)

DOI:https://doi.org/10.1016/0024-3205(87)90447-4· OSTI ID:6290851

Quock, R M; Panek, R W; Kouchich, F J; Rosenthal, M A

Exposure of rats to high levels of nitrous oxide (N2O) in oxygen reduced body temperature in a concentration-related manner. The hypothermia was partly reversed by pretreatment with naloxone but not naltrexone. But in rats rendered tolerant to morphine by pellet implantation, exposure to 75% N2O/25% O2 evoked a marked hypothermia similar to that observed in morphine-naive animals. In another experiment, the hypothermic effect of chloral hydrate was also sensitive to antagonism by pretreatment with naloxone but not naltrexone. These observations lead the authors to suspect that N2O-induced hypothermia in rats is possibly not mediated by opiate receptors. The thermotropic activity of N2O may result from some non-opioid action of N2O. Its selective antagonism by naloxone (but not naltrexone) may be due to a unique non-opioid analeptic action of naloxone. 32 references, 4 figures.

• Research Organization: Marquette Univ. School of Dentistry, Milwaukee, WI
• OSTI ID: 6290851
• Journal Information: Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 41:6; ISSN LIFSA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY TEMPERATURE
CHALCOGENIDES
DATA
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
HYPOTHERMIA
INFORMATION
MAMMALS
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
NUMERICAL DATA
OXIDES
OXYGEN COMPOUNDS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
TOXICITY
VERTEBRATES