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Synthesis, molecular structure, and absolute configuration of 1-. cap alpha. -phenylethyl-3-(2-cyanoethyl)-4-piperidone

Journal Article · · Chem. Heterocycl. Compd. (Engl. Transl.); (United States)
OSTI ID:6290827
The Michael addition of acrylonitrile to the pyrrolidine enamine of 1-(S-..cap alpha..-phenyl-ethyl)-4-piperidone proceeds with the formation of a 1:1 mixture of 1-(S-..cap alpha..-phenyl-ethyl)-3-(2-cyanoethyl)-4-piperidone diastereomers. A diastereomer isolated in pure form was shown by x-ray diffraction structural analysis to have S-configuration of the new chiral center at C/sub (3)/ of the piperidone ring.
Research Organization:
M.V. Moscow State Univ., USSR
OSTI ID:
6290827
Journal Information:
Chem. Heterocycl. Compd. (Engl. Transl.); (United States), Journal Name: Chem. Heterocycl. Compd. (Engl. Transl.); (United States) Vol. 21:12; ISSN CHCCA
Country of Publication:
United States
Language:
English

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