The solubility of hydrophobic aromatic chemicals in organic solvent/water mixtures
The influence of dissolved organic solvents on the aqueous phase solubility of hydrophobic aromatic chemicals was investigated. To provide a basis for a comprehensive evaluation of the importance of cosolvent properties on solubility, the effects of several different organic cosolvents on the solubility of a model hydrophobic solute, naphthalene, were determined. Naphthalene solubility was measured in binary, ternary, and quaternary alcohol/water (methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol) mixtures, binary ketone/water (acetone, methylethylketone, diethylketone), and aromatic organic solvent/water (benzene, toluene) mixtures. The solubility data were statistically evaluated and used to obtain an estimate of the overall accuracy of solubility measurements of hydrophobic chemicals in organic solvent/water mixtures. An accurate data base for mixed solvent solubility was established by combining the solubility data with additional solubility data obtained experimentally and from the literature. Thermodynamic models for predicting solubility in organic solvent/water mixtures were tested against the experimental data. The effects of organic cosolvent properties and solute hydrophobicity on solubility behavior and model predictive capability were evaluated. The results were used to evaluate the accuracy of existing models for predicting solubility and to explore possible molecular interactions in organic solvent/water mixtures.
- Research Organization:
- Wisconsin Univ., Madison, WI (USA)
- OSTI ID:
- 6290508
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400201* -- Chemical & Physicochemical Properties
ACETONE
ALCOHOLS
ALKYLATED AROMATICS
AROMATICS
BENZENE
BINARY MIXTURES
BUTANOLS
CONDENSED AROMATICS
DISPERSIONS
ETHANOL
FORECASTING
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
KETONES
MATHEMATICAL MODELS
METHANOL
MIXTURES
NAPHTHALENE
ORGANIC COMPOUNDS
ORGANIC SOLVENTS
OXYGEN COMPOUNDS
PARTICLE MODELS
PENTANOLS
PROPANOLS
SOLUBILITY
SOLVENT PROPERTIES
SOLVENTS
STATISTICAL MODELS
THERMODYNAMIC MODEL
TOLUENE
WATER