Blood flow and tracer uptake in normal and abnormal canine bone: comparisons with Sr-85 microspheres, Kr-81m, and Tc-99m MDP

Journal Article · Tue May 01 04:00:00 EDT 1979 · J. Nucl. Med.; (United States)

OSTI ID:6289964

Lavender, J P; Khan, R A.A.; Hughes, S P.F.

The bone scan, showing the 4-hr residue in bone of technetium diphosphonate, is a widely used diagnostic tool. The question arises whether it reflects changes in local blood flow to bone, or avidity, or both. Two experimental approaches have been used in trying to answer this question. The first was to determine immediate single-passage clearance and 4-hr residue in normal and abnormal bone. If flow is the determinant of residue these should be the same since, in this event, extraction will not change. An osteotomy was produced in the dog tibia and retrograde catheterization of the anterior tibial artery allowed measured amounts of technetium-methylene-diphosphonate (Tc-99m MDP), to be infused into the nutrient artery. Similar preparation in normal bone allowed comparison of both clearance and 4-hr residue. Results have shown increased 4-hr residue 10 days after the osteotomy (normal 4.9% ..-->.. 13.4%). The second approach involved use of a gamma camera to record profiles of blood flow in normal and abnormal bone: (a) by injecting Sr-85 microspheres into the nutrient artery, and (b) by infusing the short-lived radioactive gas, krypton-81m, thus producing an image of regional distribution of flow. Comparison of these profiles with the distribution of Tc-99m MDP shows that a moderate increase in flow is associated with a much greater increase in Tc-99m MDP residue. We conclude that, although blood flow is one determinant of the distribution of bone-seeking radionuclides such as Tc-99m MDP, some other determinants of clearance and residue explain their localization.

• Research Organization: Hammersmith Hospital, London, England
• OSTI ID: 6289964
• Journal Information: J. Nucl. Med.; (United States), Journal Name: J. Nucl. Med.; (United States) Vol. 20:5; ISSN JNMEA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
550901 -- Pathology-- Tracer Techniques
551001 -- Physiological Systems-- Tracer Techniques
560172 -- Radiation Effects-- Nuclide Kinetics & Toxicology-- Animals-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALINE EARTH ISOTOPES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL ACCUMULATION
BLOOD FLOW
BODY
BONE TISSUES
COMPARATIVE EVALUATIONS
CONNECTIVE TISSUE
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOGS
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
EVEN-ODD NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KRYPTON 81
KRYPTON ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MEASURING METHODS
MICROSPHERES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
ORGANS
PHOSPHONIC ACID ESTERS
RADIOACTIVE MATERIALS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RETENTION
SCINTISCANNING
SECONDS LIVING RADIOISOTOPES
SKELETAL DISEASES
SKELETON
STRONTIUM 85
STRONTIUM ISOTOPES
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES