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Pathophysiologic effects of stable iodine used as a thyroidal blocking agent to reduce thyroid radiation exposure. Final progress report, November 1, 1976--December 31, 1977

Technical Report ·
DOI:https://doi.org/10.2172/6289536· OSTI ID:6289536
;
In order to determine whether acute administration of iodide leads to any undesirable effects in the general population, we studied a group of patients who received iodinated radiographic contrast medium in the course of routine x-ray diagnostic procedures. We were particularly interested in investigating the possibility that administration of iodine could damage thyroid follicular cells leading to release of intrathyroidal antigens such as thyroglobulin into the blood. An increase in serum thyroglobulin might, in turn, either initiate or exacerbate thyroid autoimmunity in susceptible individuals, leading to autoimmune thyroiditis. We looked for undesirable effects due to the administration of iodide in 3 ways: a possible acute toxic effect on thyroid follicular cells was investigated by determining serum thyroglobulin immediately prior to and 24 hours after injection of iodinated contrast medium; an effect on thyroid autoimmunity was investigated by determining thyroid autoantibodies immediately prior to and 3 to 6 months after injection of iodinated contrast medium; and acute and chronic effects on thyroid function were investigated by performing thyroid function tests immediately prior to, 24 hours after and 3 to 6 months after injection of iodinateed contrast medium.
Research Organization:
Cornell Univ., New York (USA). Dept. of Medicine
OSTI ID:
6289536
Report Number(s):
COO-3173-18
Country of Publication:
United States
Language:
English

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Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTIBODIES
BIOLOGICAL EFFECTS
BIOMEDICAL RADIOGRAPHY
BODY
CONTRAST MEDIA
DIAGNOSTIC TECHNIQUES
DISEASES
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
GLOBULINS
HALOGENS
IMMUNITY
IODINE
MEDICINE
NONMETALS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PATIENTS
PROTEINS
RADIOLOGY
THYROGLOBULIN
THYROID
THYROIDITIS