Mortality among females employed by the Los Alamos National Laboratory: an epidemiologic investigation

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:6289323

Wiggs, L D

An epidemiologic investigation of mortality among 6790 females employed by the Los Alamos National Laboratory from 1943-1981 is reported. This investigation focused on two questions. First, it sought to determine whether mortality among members of this cohort differed significantly from mortality among females in the United States population. Secondly, it sought to determine whether workers exposed to radiation in their jobs were at an increased risk of dying from cancer compared with workers who were never exposed to radiation at work. To address the first question, standardized mortality analyses, using US death rates to generate expected values, were conducted. In general, observed mortality was less than expected, and no cause significantly exceeded expectation. The standardized mortality ratios (SMRs) were 76 and 78 for all causes and all cancers, respectively. To address the second question, stratified analyses directly comparing mortality rates for radiation-exposed and nonexposed members of the cohort were conducted. Rate ratios for cancers of the ovary and pancreas were found to be significantly elevated.

• Research Organization: Oklahoma Univ., Oklahoma City (USA). Health Sciences Center
• OSTI ID: 6289323
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
NEOPLASMS
RADIOINDUCTION
OVARIES
PANCREAS
EPIDEMIOLOGY
FEMALES
LASL
MORTALITY
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
RISK ASSESSMENT
BODY
DIGESTIVE SYSTEM
DISEASES
ENDOCRINE GLANDS
FEMALE GENITALS
GLANDS
GONADS
NATIONAL ORGANIZATIONS
ORGANS
US AEC
US DOE
US ERDA
US ORGANIZATIONS
560151* - Radiation Effects on Animals- Man