Acute effects of breathing inert dust particles and of carbachol aerosol on the mechanical characteristics of the lungs in man. Changes in response after inhaling sympatho-mimetic aerosols
Journal Article
·
· J. Clin. Invest.; (United States)
Five volunteers inhaled coal dust and calcium carbonate (among others) for 2-min periods. Aerosols generated from powder and were separated in a gravity flask filtration system (< 5 ..mu..m diameter particles yielded). Inhalation amounts were approx. 10 mg coal dust and 20 mg calcium carbonate. There was a mean increase in R/sub L/ from 1.83 to 3.29 cm H/sub 2/O per liter-sec. There was an increase in R/sub a/ from 1.46 to 2.63 5 to 10 min after initial inhalation with a subsequent decrease (though not necessarily to control value). A high variability with standard deviation approaching means was noted.
- OSTI ID:
- 6288317
- Journal Information:
- J. Clin. Invest.; (United States), Journal Name: J. Clin. Invest.; (United States) Vol. 37; ISSN JCINA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
551000 -- Physiological Systems
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BIOLOGICAL FUNCTIONS
CALCIUM CARBONATES
CALCIUM COMPOUNDS
CARBON COMPOUNDS
CARBONATES
COAL FINES
COLLOIDS
DISPERSIONS
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
MAMMALS
MAN
OXYGEN COMPOUNDS
PARTICLES
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SOLS
VERTEBRATES
560306* -- Chemicals Metabolism & Toxicology-- Man-- (-1987)
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
AIR POLLUTION
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
BIOLOGICAL FUNCTIONS
CALCIUM CARBONATES
CALCIUM COMPOUNDS
CARBON COMPOUNDS
CARBONATES
COAL FINES
COLLOIDS
DISPERSIONS
HAZARDS
HEALTH HAZARDS
INHALATION
INTAKE
MAMMALS
MAN
OXYGEN COMPOUNDS
PARTICLES
POLLUTION
PRIMATES
RESPIRATORY SYSTEM
SOLS
VERTEBRATES